Neuroimmunology, Endocrine and Autonomic Regulation

Ulrike Ehlert

 

Prof. Dr. Ulrike Ehlert
Department of Psychology, University of Zurich
u.ehlert@psychologie.uzh.ch

 

Topic: Endocrine and Autonomic Regulation, Neuroimmunology

Website: http://www.psychologie.uzh.ch/fachrichtungen/klipsypt_en.html

 

   
Adriano Fontana

 

Prof. Dr. Adriano Fontana
Immunology Clinic, University Hospital Zurich & Institute of Experimental Immunology, Inflammation and Sickness Behavior, University of Zurich
fontana.adriano7@gmail.com

Topic: Neuroimmunology
Website: http://www.immunology.uzh.ch

 

   
Melanie Greter

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Prof. Dr. Melanie Greter
Experimental Immunology, University of Zurich
greter@immunology.uzh.ch

Research Focus: The mononuclear phagocyte system (MPS) is defined as a group of myeloid cells comprised of monocytes, macrophages and dendritic cells. The different members of the MPS display substantial heterogeneity in terms of ontogeny, turnover and functional properties during homeostasis and inflammation. Our goal is to identify key molecules necessary for the development and function of the MPS. We will focus on microglia, a specialized brain-resident macrophage population. We aim to discover new lineage guiding transcription factors involved in microglia regulation. In addition, we will generate new mouse strains in order to specifically target microglia in vivo and to genetically manipulate CNS-invading monocytes during neuroinflammation.

Keywords: Microglia, macrophages, cytokines, development, neuroinflammation

Topic: Neuroimmunology

Publications: pubmed

Website: http://www.immunology.uzh.ch

 

   
Foto Langhans

 

Prof. Dr. Wolfgang Langhans
Physiology and Behavior Laboratory, Institute of Food, Nutrition and Health, ETH
wolfgang-langhans@ethz.ch

 

Topic: Endocrine and Autonomic Regulation

Website: http://www.fpb.ethz.ch/index_EN

 

   
Foto luenemann

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Prof. Dr. med. Jan Lünemann
Laboratory of Neuroinflammation, Institute of Experimental Immunology, University of Zurich
jan.luenemann@uzh.ch

Research Focus: Genetic and environmental factors jointly determine the susceptibility to develop autoimmune diseases such as multiple sclerosis (MS). Allelic variants within the major histocompatibility complex (MHC) class II region are strongly associated with MS susceptibility and we are investigating mechanisms by which antigen presentation permits CD4+ T cell-mediated CNS tissue injury in animal models of MS. In addition, we aim at identifying mechanisms how environmental insults interact with genetic risk factors and are currently investigating immune responses to viral pathogens associated with MS, such as Epstein Barr Virus (EBV) to develop therapeutic strategies aiming at preventing EBV-associated MS risk. Furthermore, we explore mechanisms of antibody-mediated immunotherapies in neuroinflammatory diseases.

Keywords: Multiple Sclerosis, Immunotherapy, Antibody, Antigen Presentation

Topic: Neuroimmunology

Publications: pubmed

Website:http://www.immunology.uzh.ch/researchunit/neuroinflammation.html

 

   
Andreas Lutterotti

 

Prof. Dr. med. Andreas Lutterotti
Department of Neurology, University Hospital Zurich
andreas.lutterotti@usz.ch

Research Focus: The main goal of the experimental therapies unit is to approach unmet medical needs in MS with new therapeutic strategies and to assess their safety and efficacy in early phase clinical trials. These experimental trials will be accompanied by mechanistic studies aiming to adress the mechanisms of action of the treatments and the pathogenesis of the disease.

Our current research focuses on a novel strategy to induce antigen-specific tolerance in multiple sclerosis. Further we follow novel strategies to approach neuroinflammation and neuroprotection in MS.

Keywords: multiple sclerosis, immune tolerance, antigen-specific, neuroprotection

Topic: Neuroimmunology

Publications: pubmed

Website: http://www.multiplesclerosis.uzh.ch/coretopics/lutterotti.html

 

   
Roland Martin

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Prof. Dr. med. Roland Martin
Dept of Neuroimmunology and MS Research (nims), Neurology Clinic, University Hospital Zurich
roland.martin@usz.ch

Research Focus: The focus of our research is to understand better the disease heterogeneity of Multiple Sclersosis using imaging techniques (MRI and optical coherence tomography, OCT), biological markers and motor function. In the laboratory we examine disease mechanisms of MS with particular focus on cellular immunology and biochemistry. We strive at developing new treatments particularly in areas of unmet medical needs of MS such as neuroprotection, induction of tolerance and regenerative therapies.

Keywords:  Multiple sclerosis, T cell, antigen-specific tolerization, progressive multifocal leukoencephalopathy, experimental therapy

Topic: Neuroimmunology

Publications: pubmed

Websites: http://www.neurologie.usz.ch/forschung/

http://www.multiplesclerosis.uzh.ch/index.html

 

   
suter_t

 

Dr. sc. nat. ETH Tobias Suter

Dr. sc. nat. ETH Tobias Suter
Department of Molecular Mechanisms of Disease, University of Zurich
tobias.suter@uzh.ch

Topic: Neuroimmunology

Publications: pubmed

Website: http://www.dmmd.uzh.ch