Workshop 1

Induced pluripotent stem cell models in neuroscience
(Lecture Hall E3)

Since the discovery by Yamanaka and Takahashi of induced pluripotent stem cells (iPSC), this technology has opened unprecedented possibilities to study virtually any cell type of interest in vitro and to model human diseases “in a dish”. Applications of iPSC-based technology have been particularly valuable in neuroscience, where access to living human neuronal cells is exceedingly challenging. Today, an abundance of protocols for 2D and 3D differentiation into various neuronal cell types are available. In this workshop, four lectures will cover various applications of iPSC-based methods in different fields of neuroscience, addressing a broad range of fundamental questions including human neurogenesis, pathological mechanisms of neurodegenerative diseases and of neurodevelopmental and psychiatric disorders. 

Introduction and Moderation
Prof. Edna Grünblatt, Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich (PUK)

Dr. Christian Tackenberg, Institute for Regenerative Medicine, UZH
Prof. Ruxandra Bachmann-Gagescu, Institute of Medical Genetics, UZH

10:00 - 10:45

Modelling human neurogenesis with cerebral organoids
Dr. Silvia Cappello, Max Planck Institute of Psychiatry, München
 

10:45 - 11:00

Generating iPSC-based models for a neurodevelopmental ciliopathy
Affef Abidi and Melanie Eschment, Institute of Medical Genetics, UZH

 

11:00 - 11:15

Modelling Alzheimer's Disease with iPSC-derived neural cells
Sherida de Leeuw, Institute for Regenerative Medicine, UZH
 

11:15 - 11:30

Modelling ADHD neurodevelopmental alterations using iPSCs
Sakshi Bansal, Translational Molecular Psychiatry, KJPP, PUK