Alphabetical List

A      
 
Peter Achermann

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Prof. Dr. sc.nat. Peter Achermann
Institute of Pharmacology and Toxicology, University of Zurich

acherman@pharma.uzh.ch
Research Focus: Our research interests are sleep, sleep regulation and circadian rhythms with a focus on mathematical modeling and biosignal analysis and effects of exposure to electromagnetic fields on brain activity. In collaboration with clinicians, we also investigate altered sleep regulation in patients. Our current focus is on resting state networks and sleep regulation, sleep onset and other state transitions, functional and effective connectivity between brain networks during sleep, automatic artifact detection, and continuous monitoring of brain state changes (e.g. detection of microsleep episodes)

Keywords: sleep and sleep regulation, circadian rhythms, mathematical modeling and biosignal analysis, imaging of sleep
Topics:
Sleep and Sleep Disorders, Computation and Modeling
Projects: project data bank UZH

Publications: researcherid.com  scholargoogle.ch

Website:  http://www.pharma.uzh.ch/research/chronobiology/areas/sleepbiology.html

 

      

 

 
   
aguzzi

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  Prof. Dr. Adriano Aguzzi
Institute of Neuropathology, University Hospital Zurich
adriano.aguzzi@usz.ch

Research Focus: We have devoted the past 20 years to studying the immunological and molecular basis of prion pathogenesis. Currently, the primary focus of the lab lies on elucidating mechanisms underlying a) replication of prions and prion-like proteins such as alpha-synuclein and b) neurotoxicity in prion diseases. We approach these objectives from different directions. On one hand, we have established highly automated platforms for cell-based assays in order to screen for genes that are important for either prion replication or toxicity. On the other hand, we use a variety of model systems for genetic and infectious prion disease including cell culture models such as human IPS-cell derived neurons, ex vivo brain slice cultures and various transgenic and knockout mouse models in order to investigate molecular pathways underlying prion toxicity and pathogenesis.

Keywords: Neurodegeneration, neurotoxicity, prion disease, organotypic brain slice cultures, generation of transgenic and knock-out mouse models, high-throughput screenings

Topic: Disorders of the Nervous System

Publications:http://www.zora.uzh.ch/view/subjectsnew/10208.html

https://scholar.google.com

Website: http://www.en.neuropathologie.usz.ch/

 

 

   

Ametamey

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Prof. Dr. Simon M. Ametamey

Institute of Pharmaceutical Sciences, Animal Imaging Center-PET, ETH Zurich
simon.ametamey@pharma.ethz.ch

Research Focus: Research in our group focuses on the development of positron emission tomography (PET) radiopharmaceuticals for the diagnosis of neurodegenerative diseases in the central nervous system (CNS). Specific research activities include the glutamatergic and the cannabinoid neurotransmission systems. Several established CNS PET ligands are also routinely synthesized and applied for drug development and studying brain functions.

Keywords: PET radioligand, in vivo imaging, drug development, glutamatergic and cannabinoid neurotransmission systems

Topic: Biomedical Technology and Imaging

Publications: pubmed

Website: http://www.radiopharmaceutical-science.ethz.ch

 

   
Irmgard Amrein

 

PD Dr. Irmgard Amrein
Division of Functional Neuroanatomy, Institute of Anatomy, University of Zurich

i.amrein@anatom.uzh.ch

Research focus: We investigate eco-evolutionary adaptations in the structure of the mammalian hippocampus – How do structural specializations relate to the evolutionary history of animals? How do structural specializations translate into behaviors that allow the animals to successfully compete in their ecological niches? We perform comparative quantitative analysis of functionally defined neuron populations that also includes neurons that are born in adult animals. Most of the animals we study are wild-living species that show unique environmental adaptations. We have been able to define anatomical patterns that characterize taxonomic groups, and within these groups, habitat requirements that can shape quantitative relations between hippocampal cell populations - revealing surprising features that only nature is able to create.

Keywords: hippocampus, behavior, adaptation, phylogeny, stereology, immunohistochemistry, neurogenesis

Topic: Neural Basis of Behavior

Publications: pubmed

 

   
Margarete Arras

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PD Dr. med. vet. Margarete Arras
Center for Clinical Research, Division of Surgical Research, University Hospital Zurich
margarete.arras@usz.ch
Research Focus: Pain in rodents is still a contradictory topic. Currently only few reliable indicators exist to detect low and middle grade pain in the mouse. As the diagnosis of pain is the basis of effective analgesic treatment for animals used in biomedical research, the analgesic regimens currently used for mice often do not meet the needs of this species. We therefore work on the development of reliable and sensitive indicators in different pain models and use our pain indicators to test and adjust analgesic regimens for mice undergoing diverse experimental procedures.

Methods used: Telemetric recordings of physiological parameters, observations of species typical behaviours in the home cage, analyses of activity and circadian rhythm, behavioural tests e.g. burrowing test, analgesiometric and pharmacokinetic investigations.

Keywords: Pain, refinement, analgesia, behavior, mouse

Topic: Neural Basis of Behavior

Publications: pubmed

Website: http://www.chir.uzh.ch/anesthesia.html

   
Ayaz Asli

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Dr. Asli Ayaz
Brain Research Institute, University of Zurich
ayaz@hifo.uzh.ch

Research Focus: We perceive the outside world as a result of continuous sensorimotor interactions. We guide our gaze to what we want to look at; we choose and approach what to touch smell or taste.  In addition our motor actions are carried out in the light of sensory inputs. Our research focuses on understanding how sensory inputs are integrated with motor actions to produce a unified percept. We specifically investigate sensorimotor circuitry of somatosensation during active exploratory behavior in head-restrained mobile mice. We use 2-photon calcium imaging to measure neuronal activity and benefit from viral and genetic constructs to dissect and manipulate the circuitry.

Keywords: sensory processing, locomotion, in vivo physiology, optical imaging, sensorimotor integration, neural circuits

Topics: Sensory systems, Neural basis of behavior

Website: https://sites.google.com/site/asliayazhomepage/home

 

   
B      
Dominik Bach

 

Prof. Dr. phil. Dr. med. Dominik R. Bach
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich
dominik.bach@uzh.ch

Research Focus:  Emotions are adaptive response syndromes that exist in humans, and non-human animals. Our knowledge on the molecular and neuronal basis of defensive emotions such as panic, learned fear, and anxiety, mainly comes from animal research. Yet, animal models of emotion are not directly comparable to human emotion. The challenge that our lab seeks to address is to translate established animal models of emotion to humans, by creating and investigating behavioural cross-species test beds. We are particularly interested in a computational formulation of aversive learning (fear conditioning), anxiety, and other defensive behaviours. To this end, we use structural and functional MRI, MEG, peripheral physiology, behavioural experiments, and computational modelling.

Keywords: Emotions, comparative neuroscience, computational modelling, fear conditioning, anxiety

Topics: Neural Basis of Behavior, Cognitive Neuroscience, Computation and Modeling

Publications: pubmed

Website: http://bachlab.org

 

   
Bachmann Ruxandra

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Dr. med. Ruxandra Bachmann-Gagescu
Institute for Molecular Life Sciences, University of Zurich
ruxandra.bachmann@imls.uzh.ch

Research Focus: Our research focuses on a group of human Mendelian disorders called ciliopathies which are unified by shared genetic causes resulting in primary cilium dysfunction. Primary cilia are small non-motile organelles present on the surface of most vertebrate cells where they are involved in transduction of sensory, mechanical or chemical signals and in regulation of signalling pathways during development and cell homeostasis. Typical clinical presentations of ciliopathies include neurological involvement, retinal degeneration and renal fibrocystic disease, as illustrated by Joubert syndrome (JS), an iconic ciliopathy which is the main focus of our research. To understand the consequences of mutations in JS-associated genes at the molecular level, we combine observations from human genetics studies on JS-patients with modelling in the zebrafish system using state-of-the-art techniques such as crispr/Cas9 genome editing or live imaging of transgenically-tagged ciliary proteins.

Keywords: ciliopathies, primary cilia, Joubert syndrome, zebrafish

Topics: Development and Regeneration, Disorders of the nervous system

Website: http://www.medgen.uzh.ch/en/forschung/Research-Group-Bachmann-Gagescu.html

 

   
C      
Giovanni Camici

 

PD Dr. Giovanni G. Camici
Head of Center for Molecular Cardiology, University of Zurich
giovanni.camici@uzh.ch

Research Focus: Molecular mechanisms by which aging affects vascular function and how these mechanisms are relevant to major age-related disorders such as stroke. The main hypothesis of this team is based on the idea that aging and cerebrovascular disease such as stroke, occur through similar mechanisms oftentimes involving the generation of highly reactive and deleterious “reactive oxygen species” (ROS). In line with this hypothesis, several genes which mediate the process of aging are also involved in the generation of ROS.

Keywords: Aging, stroke, vascular/endothelial dysfunction, thrombosis, ROS.

Topic: Molecular and Cellular Neuroscience

Publications: pubmed

Website: http://www.cmc.uzh.ch/index.html

 

   
christen

 

PD Dr. sc. ETH Markus Christen

Institute of Biomedical Ethics and History of Medicine & UZH Digital Society Initiative, University of Zurich

christen@ethik.uzh.ch
Research Focus: The Neuro-Ethics-Technology research group of the Institute of Biomedical Ethics and History of Medicine investigates research topics at the interfaces of ethics, neuroscience/-psychology and information technology. We use both empirical and normative methodologies in currently nine different research projects. Those research fields are: research on moral intelligence components, family life, health & moral development, brain death and transplantation, serious moral games, ethics of neuromodulation, moral decision making and autonomous systems, Big data ethics, visualizing morally loaded data, cybersecurity and ethics.

Keywords: neuroethics; deep brain stimulation; brain death; big data ethics; moral psychology; ethics of information technology
Topics: Biomedical Technology; Cognitive Neuroscience; Motor Systems
Projectshttp://www.research-projects.uzh.ch/a1026.htm

Publicationshttps://www.encyclog.com/forschung/person/publikationen

Website: http://www.ibme.uzh.ch/de/ethik/forschung/Neuro-Ethics-Technology-(NET)-Research-Group.html 

 

   
Mathew Cook

 

Dr. Mathew Cook
Institute of Neuroinformatics, University and ETH Zurich
cook@ini.uzh.ch

 

Topic: Computation and Modeling

Website: http://www.ini.uzh.ch/people/cook

 

   
Armin Curt

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Prof. Dr. med. Armin Curt
Balgrist University Hospital, Spinal Cord Injury
Armin.Curt@balgrist.ch

Research Focus: Recovery in human SCI (in accordance to animal studies) is based on multiple mechanisms not limited to the spinal cord (repair and modulation of longitudinal fibre tracts) but as well at the supraspinal level (reorganization of brain function), within motor units (sprouting) and muscle properties (electromechanical coupling). Outcomes in human acute SCI are rather well predictable by combined clinical (neurological scoring) and neurophysiological (MEP, SSEP, NCS, EMG etc..) and neuroimaging (MRI) recordings and mechanisms of clinical recovery can be attributed to either effects based on the adjustment of movement strategies (achieving ADLs by alternative approaches and technical aids) or compensation of body function (optimized training of preserved motor/sensory function).

Improving the assessment of spinal cord fibre tracts and spinal cord segments in acute SCI and during recovery to introduce more sensitive and responsive measures for the evaluation of neural repair and plasticity. The latter is utmost important to provide tools for the proof of mechanisms and clinical meaningfulness of new interventions (translational research) in human SCI as being developed in pre-clinical (animal) studies.

Keywords: Spinal cord injury, rehabilitation, locomotion, repair in human spinal cord injury, hand/arm function in cervical spinal cord injury, outcome measures, intervention.

Topic: Disorders of the Nervous System

Publications: pubmed

   

 

D      
Moritz Daum