Alphabetical List
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Prof. Dr. Adriano Aguzzi Research Focus: We have devoted the past 20 years to studying the immunological and molecular basis of prion pathogenesis. Currently, the primary focus of the lab lies on elucidating mechanisms underlying a) replication of prions and prion-like proteins such as alpha-synuclein and b) neurotoxicity in prion diseases. We approach these objectives from different directions. On one hand, we have established highly automated platforms for cell-based assays in order to screen for genes that are important for either prion replication or toxicity. On the other hand, we use a variety of model systems for genetic and infectious prion disease including cell culture models such as human IPS-cell derived neurons, ex vivo brain slice cultures and various transgenic and knockout mouse models in order to investigate molecular pathways underlying prion toxicity and pathogenesis. Keywords: Neurodegeneration, neurotoxicity, prion disease, organotypic brain slice cultures, generation of transgenic and knock-out mouse models, high-throughput screenings Topic: Disorders of the Nervous System Publications: zora Google Scholar Website: http://www.en.neuropathologie.usz.ch/
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PD Dr. Irmgard Amrein Research focus: We investigate eco-evolutionary adaptations in the structure of the mammalian hippocampus – How do structural specializations relate to the evolutionary history of animals? How do structural specializations translate into behaviors that allow the animals to successfully compete in their ecological niches? We perform comparative quantitative analysis of functionally defined neuron populations that also includes neurons that are born in adult animals. Most of the animals we study are wild-living species that show unique environmental adaptations. We have been able to define anatomical patterns that characterize taxonomic groups, and within these groups, habitat requirements that can shape quantitative relations between hippocampal cell populations - revealing surprising features that only nature is able to create. Keywords: hippocampus, behavior, adaptation, phylogeny, stereology, immunohistochemistry, neurogenesis Topic: Neural Basis of Behavior Publications: PubMed
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Prof. Dr. med. Ruxandra Bachmann-Gagescu Research Focus: Our research focuses on a group of human Mendelian disorders called ciliopathies which are unified by shared genetic causes resulting in primary cilium dysfunction. Primary cilia are small non-motile organelles present on the surface of most vertebrate cells where they are involved in transduction of sensory, mechanical or chemical signals and in regulation of signaling pathways during development and cell homeostasis. Typical clinical presentations of ciliopathies include neurological involvement, retinal degeneration and renal fibrocystic disease, as illustrated by Joubert syndrome (JS), an iconic ciliopathy which is the main focus of our research. To understand the consequences of mutations in JS-associated genes at the molecular level, we combine observations from human genetics studies on JS-patients with modelling in the zebrafish and in human iPSC-derived neurons using state-of-the-art techniques such as CRISPR/Cas9 genome editing or live imaging of transgenically-tagged ciliary proteins. Keywords: ciliopathies, primary cilia, Joubert syndrome, zebrafish, iPSC Topics: Development and Regeneration, Disorders of the nervous system Website: http://www.medgen.uzh.ch
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Prof. Dr. Christian Baumann Department of Neurology, University Hospital Zurich
Topic: Sleep and Sleep Disorders Website: http://www.neurologie.usz.ch
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Prof. Dr. rer. nat. Burkhard Becher Research Focus: Neuro- and Tumorimmunology Our research aims to understand the development of tissue-specific autoimmunity in particular in the context of interactions of the nervous system with the immune system. Our main research interests can be categorized as such:
Keywords: Transgenic mice, cytokines, immunity Topic: Disorders of the Nervous System Publications: PubMed Website: http://www.immunology.uzh.ch/ |
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Prof. Dr. rer. nat. Elvir Becirovic Research Focus: Millions of people worldwide suffer from various forms of retinal diseases that can lead to total blindness. Especially for the inherited forms of retinal diseases, there is an unmet medical need for the development of new molecular genetic diagnostic and therapeutic methods. My group works at the interface between basic research and therapy of inherited retinal diseases (IRDs). In this context we pursue several goals:
Keywords: gene therapy, retina, inherited retinal diseases, gene editing, epigenome editing, AAV vectors, molecular diagnosis, retinal organoids, CRISPR-Cas, CRISPRa, IRDs Topic: Disorders of the Nervous System, Sensory Systems Website: https://www.usz.ch/team/elvir-becirovic/
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PD Dr. Susanne Becker Research Focus: The experience of pain is more than the conscious perception of nociceptive signals. Emotional and motivational aspects accompany pain, leading to its aversiveness and motivation for escape and avoidance. Moreover, it has been proposed that a negative hedonic shift, comprising unproportionally increased emotional-motivational pain responses, plays an important role in the development and maintenance of chronic pain. Our group focuses on the investigation of psychobiological mechanisms of dissociations of emotional-motivational and sensory-discriminative components of pain in health and disease states, using psychophysical methods, pharmacological interventions, and brain imaging techniques. Specifically, we investigate the role of the neurotransmitter dopamine, functional connectivity in fronto-striatal brain networks, and supraspinal neuroinflammation in the proposed negative hedonic shift in chronic pain. Keywords: pain modulation, emotional-motivational pain processing, dopamine, fMRI, psychophysics Topic: Cognitive Neuroscience, Sensory Systems Publications:Google Scholar Website: https://www.balgrist.ch/ |
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PD Dr. Dietmar Benke Institute of Pharmacology and Toxicology, University of Zurich Research Focus: GABAB receptors control neuronal excitability by mediating slow inhibitory neurotransmission. They are involved in virtually all main brain functions and have been implicated in numerous neurological disorders making them attractive drug targets. Our research focuses on the regulation of GABAB receptors by trafficking mechanisms and interacting proteins under normal and pathological conditions. Our ultimate goal is to uncover mechanisms of GABAB receptor dysregulation in disease states and use this information for designing novel therapeutic strategies. Current projects concentrate on the regulation of GABAB receptor cell surface expression by phosphorylation, ubiquitination and interacting proteins and its contribution to neuronal plasticity. In addition, we explore the potential to prevent downregulation of GABAB receptors in cerebral ischemia with small synthetic peptides interfering with protein-protein interactions as a novel neuroprotective strategy. Keywords: GABAB receptor, trafficking, plasticity, neurological disorders Topic: Molecular and Cellular Neuroscience Publications: PubMed Website: http://www.pharma.uzh.ch
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Prof. Dr. Wolfgang Berger Institute of Medical Molecular Genetics, University of Zurich Research Focus: Our research activities are focussing on genetic diseases of the retina. We have identified a number of genes and mutations involved in Mendelian traits. High throughput sequencing technologies (NGS) are used to identify additional mutations and novel genes. Mouse models are being used to study the pathophysiology of monogenic human diseases as a prerequisite to implement therapeutic approaches. Additional areas of research include angiogenic processes in the retina and brain, pre mRNA splicing as well as gene-therapeutic approaches for treatment of retinal degenerations. Keywords: Eye diseases, genetic associations, therapeutic intervention, retinal development and diseases Topic: Sensory Systems Publications: http://www.medmolgen.uzh.ch Website: https://www.medmolgen.uzh.ch
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Dr. Giovanni Bertolini, Junior Group Leader Department of Neurology, University of Zurich Research Focus: The aim of the Swiss Space Travel and AiR Sickness (SSTARS) group is to investigate the mechanism of habituation and learning of self-motion perception in novel motion environments. A novel motion environment is any condition in which our brain fails to correctly interpret the motion stimuli. Such environments (from cars and ships to virtual reality and artificial gravity environments) cause motion sickness, spatial disorientation and other syndromes affecting performance and social interaction (sopite syndrome, mal de débarquement). Within our research activity, we develop non-invasive habituation protocols to counteract these conditions. The applications range from vestibular rehabilitation, acceptance of novel emerging technology (self-driving cars, virtual reality systems), quality of life and safety in transport systems. An important focus is on vestibular physiology for aviation and space flight (in flight, micro- and artificial gravity) in collaboration with the German Aerospace Center – DLR and the Swiss Aeromedical Institute. Keywords: Motion sickness, vestibular space physiology, artificial gravity, virtual reality sickness, self-motion perception, sensory habituation Topics: Sensory systems, Disorder of the nervous system, Neural Basis of Behavior Publications: Google Scholar
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Prof. Dr. Johannes Bohacek Lab of Molecular and Behavioral Neuroscience, Institute for Neuroscience, ETH Zurich Research Focus: Exposure to stressful experiences is one of the major risk factors for developing mood and anxiety disorders. My group uses mice to study the organism-wide consequences of stress in a complex mammalian system, with a focus on the locus coeruleus – noradrenaline system. In our innovative research program we combine modern multi-omic techniques (from single-cell sequencing to epigenomic screens) with circuit-neuroscience tools (e.g. optogenetics, photometry) to dissect the mechanisms that distinguish healthy stress coping from maladaptive stress-related disease. Because stress is a whole-organism response, in which the central nervous system tightly regulates energy homeostasis across the body, our work spans three major levels of analysis, from single cells to brain circuits and ultimately to behavior. Keywords: stress, anxiety, transcriptome, hippocampus, epigenetic inheritance, epigenetics Topics: Neural Basis of Behavior, Disorders of the Nervous System, Molecular and Cellular Neuroscience Publications: PubMed Website: http://www.bohaceklab.ethz.ch |
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PD Dr. Marc Bolliger University Hospital Balgrist, Spinal Cord Injury Center marc.bolliger@balgrist.ch Research Focus: Regaining locomotor function after spinal cord injury (SCI) is one of the priorities for the affected persons. The focus of our group lies on the development of new technologies to enhance the therapy outcome after SCI. In addition, we establish detailed motion capture analysis in our patients to better understand mechanism of improvements. Our interdisciplinary team consists of movement scientists, biologists, engineers and therapists and is closely connected to the clinic of the Spinal Cord Injury Center Balgrist. Keywords: Spinal cord injury, rehabilitation robotics, locomotion, movement analysis, outcome measures, intervention. Topics: Motor Systems, Disorders of the Nervous System Publications: PubMed Website: https://www.sci-research.uzh.ch
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Prof. Dr. Daniel Brandeis Research Focus: We focus on mapping brain functions and plasticity in typical development, neurodevelopmental disorders, and treatment with electrical and multimodal imaging (EEG-fMRI, MRS, with S. Brem). Clinical projects cover longitudinal brain mapping in common neurodevelopmental disorders like Attention-Deficit/Hyperactivity Disorder (ADHD), aggression and Dyslexia. We characterize timing, localization and genetics (with E. Grünblatt) of compromised networks as endophenotypes as state dependent deficits during rest, attention, inhibition, reward processing, or print tuning etc. For clinical translation we focus on neurofeedback and biofeedback training (with R. Drechsler), and evaluate potential biomarkers using multimodal approaches. Keywords: ADHD, dyslexia, OCD, conduct disorder, development, plasticity, functional brain mapping, EEG, ERP, fMRI, MRS, neurofeedback, biofeedback, longitudinal studies, reading, attention, genetics, gene x environment interactions. Topics: Disorders of the Nervous System, Development and Regeneration, Cognitive Neuroscience, Biomedical Technology and Imaging Publications: PubMed Website: http://www.kjpd.uzh.ch
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Dr. sc. nat. Silvia Brem University Clinic for Child and Adolescent Psychiatry (UCCAP), University of Zürich Research Focus: Current research interests are the use of multimodal imaging techniques (EEG, MRI) to examine i) typical and atypical reading development (developmental dyslexia), ii) prediction and intervention in dyslexia and iii) dysfunctional brain networks in child psychiatric populations such as attention deficit hyperactivity disorder (ADHD) and juvenile obsessive compulsive disorder (OCD). Keywords: EEG, MRI, simultaneous EEG-fMRI, reading, developmental dyslexia, ADHD, OCD Topics: Cognitive Neuroscience, Disorders of the Nervous System Publications: PubMed Website: http://www.kjpd.uzh.ch
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Prof. Dr. phil. Peter Brugger Research Focus: One focus is on space representation in healthy individuals and patients with hemispatial neglect. The “space” we are interested in is not confined to physical space, but comprises imagined locations, number space and the spatial representation of time. A very special, private part of space is our body. We are interested in the relations between corporeal awareness and the construction and experience of the self. This experience can change after brain damage, but can also drastically deviate from the norm in a minority of apparently healthy individuals. Cognitive dysfunction in a demyelinating disorder, multiple sclerosis, represents a further focus of interest. Here we are specifically interested in the relative contributions of white matter and gray matter lesions to cognitive performance, specifically executive functions. Generally, our strengths are in behavioral methods; structural and functional neuroimaging may complement the behavioral approach. Keywords: Processing of space and time, body and self, structural correlates of cognitive dysfunction Topics: Cognitive Neuroscience, Disorders of the Nervous System Publications: zora
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Prof. Dr. Denis Burdakov ETH Zurich, Department of Health Sciences and Technology (D-HEST) Research focus: Neural algorithms and behaviour How does the brain solve complex problems? The Burdakov lab studies brain computations that convert sensory context into appropriate actions, appetites, and arousal. Our experiments focus on specific genetically-defined brain cells, but our questions are more general, overlapping with fields such as robotics (what control algorithms are best for performance in an uncertain world? what are their strengths and weaknesses?). To answer such questions, the lab studies how information is represented by specific neural clusters to sway decisions. This is achieved by tracking real-time brain network dynamics (using in vivo genetically-targeted calcium reporters, electrophysiology) associated with quantified voluntary actions, while manipulating sensory contexts (internal and external body state) and genetically- and temporally-defined elements of neural computations (using optogenetics, chemogenetics). These sensorimotor measurements are interpreted with the help of computational simulations that formally assess the performance of particular sensorimotor algorithms in defined tasks. By elucidating what different parts of the brain do, how they do it, and what makes them perform well or badly, this work provides fundamental information that can be used for designing better medical treatments for brain disorders. Topics: Neural basis of behaviour, computation and modelling, molecular and cellular neuroscience, disorders of the nervous systems Publications: PubMed Website: https://www.hest.ethz.ch/
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Prof. Dr. Judith Burkart Research Focus: The Evolutionary Cognition Group studies human and nonhuman primates to better understand the evolutionary origin of humans’ social, motivational and cognitive processes. A particular focus is on cooperative breeding (i.e. the reproductive system where group members other than the parents significantly contribute to infant rearing) which convergently evolved in humans and marmoset monkeys. We noninvasively study marmoset monkeys in captivity and in the wild using a diverse set of approaches, including cognitive tests batteries, behavioral experiments probing their prosociality and other psychological traits, observational studies, automated behavioral monitoring, acoustic analyses, endocrinology, and thermography as noninvasive measure of emotional arousal. Keywords: comparative psychology, endocrinology, thermography, automated behavioral and acoustic monitoring, vocal communication Topics: Cognitive neuroscience, development and regeneration Publications: Google Scholar Website: https://www.aim.uzh.ch
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PD Dr. sc. ETH Markus Christen Institute of Biomedical Ethics and History of Medicine & UZH Digital Society Initiative, University of Zurich christen@ethik.uzh.ch Keywords: neuroethics; deep brain stimulation; brain death; big data ethics; moral psychology; ethics of information technology Publications: https://www.encyclog.com Website: https://www.ibme.uzh.ch/
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Dr. Mathew Cook
Topic: Computation and Modeling Website: http://www.ini.uzh.ch/people/cook
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Prof. Dr. med. Armin Curt Research Focus: Recovery in human SCI (in accordance to animal studies) is based on multiple mechanisms not limited to the spinal cord (repair and modulation of longitudinal fibre tracts) but as well at the supraspinal level (reorganization of brain function), within motor units (sprouting) and muscle properties (electromechanical coupling). Outcomes in human acute SCI are rather well predictable by combined clinical (neurological scoring) and neurophysiological (MEP, SSEP, NCS, EMG etc..) and neuroimaging (MRI) recordings and mechanisms of clinical recovery can be attributed to either effects based on the adjustment of movement strategies (achieving ADLs by alternative approaches and technical aids) or compensation of body function (optimized training of preserved motor/sensory function). Improving the assessment of spinal cord fibre tracts and spinal cord segments in acute SCI and during recovery to introduce more sensitive and responsive measures for the evaluation of neural repair and plasticity. The latter is utmost important to provide tools for the proof of mechanisms and clinical meaningfulness of new interventions (translational research) in human SCI as being developed in pre-clinical (animal) studies. Keywords: Spinal cord injury, rehabilitation, locomotion, repair in human spinal cord injury, hand/arm function in cervical spinal cord injury, outcome measures, intervention. Topic: Disorders of the Nervous System Publications: PubMed |
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Prof. Dr. phil. Moritz M. Daum Research Focus: The overarching aim of the Research Group “Developmental Psychology” is to address the roots of infants’ and young children’s perception and understanding of their social world. The understanding of others as social agents is one of the most fundamental skills in our everyday social life. It is crucial for any engagement in cooperative and communicative activities. In our research, we are particularly interested in the mechanisms that form the bedrock of infants’ action perception, the interrelation of infants’ early action perception comprehension to the control of their own actions, the selective implementation of observed actions in one’s own actions. Current projects focus on the (neuro-)cognitive processes underlying infants’ and young children’s action understanding, the interrelation of action understanding and action performance across the whole lifespan, the interrelation of language and action in development, and the development of the self. Keywords: developmental psychology, infancy, life span, cognitive development, action perception language, imitation, eye tracking, EEG Topics: Development and Regeneration, Neural Basis of Behavior, Cognitive Neuroscience Publications: PubMed Website: http://www.psychologie.uzh.ch Lab: http://www.kleineweltentdecker.ch
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Prof. Tobi Delbruck Research Focus: The sensors group at INI led by myself and PD Dr. Shih-Chii Liu develops neuromorphic silicon vison and audio sensors and methods for processing their output. These sensors and processing methods are inspired by the organizing principle of the nervous system. For instance, the brain uses spikes to transmit analog signals over long distances without losing precision by using interspike time intervals and spike coincidence to encode analog information. One of the main sensors is the dynamic vision sensor (DVS). The DVS encodes visual information by transmitting spikes in response to log intensity changes. This way, the sensor achieves very high dynamic range and can help beat the classical latency-power tradeoff suffered by conventional image sensors. We also develop many robots to demonstrate the advantages of the neuromorphic approach. Keywords: neuromorphic, sensor, vision, eye, retina, cochlea Topics: Sensory Systems, Computation and Modeling Publications: http://sensors.ini.uzh.ch Website: https://www.ini.uzh.ch
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Dr. med. habil. Igor Delvendahl Research focus: Activity-dependent plasticity of synaptic transmission is essential for learning and memory, but uncontrolled changes in synaptic transmission can lead to unfavorable levels of excitability. Dysfunctional plasticity and failure to maintain stability of synaptic transmission have been linked to various pathological conditions. Our research interests are centered on how synapses allow activity-dependent adaptations while maintaining a stable level of activity. We apply a combination of subcellular electrophysiology, functional imaging, and genetics to study synaptic transmission and plasticity at mammalian central synapses. Our research aims at unraveling fundamental mechanisms underlying robustness and plasticity of synaptic transmission with a strong focus on presynaptic function. We hope that our work will provide important conceptual insights into how synaptic transmission can be modulated under physiological and pathophysiological conditions. Topic: Molecular and Cellular Neuroscience Publications: PubMed |
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Dr. Elisa Donati, Junior Group Leader Research focus: My research activities are at the interface of neuroscience and neuromorphic engineering. My main goal is to understand how to develop event-based systems able to interface with humans to process in real-time physiological data as inputs. In particular, I am focusing on biomedical applications where the device should be implanted to restore missing biological functions, (e.g., adaptive pacemakers, biomedical devices for neuroprosthetics). In addition, I am exploring the peripherical nervous system to understand how to apply physiological models to robotic control, to build a fully event-based pipeline. Keywords: Neuromorphic, biomedical application, biomedical signal processing, electronic circuits, robotics Topic: Computation and Modeling and Motor Systems Publications: Google Scholar Website: https://www.ini.uzh.ch
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Dr. Daniel Düring, Junior Group Leader Research focus: My research focuses on resolving the structural and molecular profile and dynamic changes of neural circuits underlying vocal learning in songbirds. Songbird vocal behavior is the prime model system for studying the neural mechanisms underlying human speech development. Birdsong research holds the potential to help us understand healthy vocal systems and design better treatments for speech and language disorders, which affect millions of children worldwide. To investigate the brain circuits controlling birdsong, I use state of the art techniques, some of which I have developed in the past years, with focus on examining the ultra structure of large, unsectioned volumes of the brain using expansion and light sheet microscopy (ExLSM), and viral vector targeting strategies. Keywords: behavioral neuroscience, vocal learning, connectomics, multi-omics, structural and functional neuro-imaging, expansion light sheet microscopy, photometry, viral vector targeting, neuro-genetic sensors and effectors Topic: Neural Basis of Behavior, Molecular and Cellular Neuroscience Publications: Google Scholar Website: https://www.ini.uzh.ch |
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Prof. Dr. Ulrike Ehlert
Topic:Neuroimmunology, Endocrine and Autonomic Regulation Website: https://www.psychologie.uzh.ch
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Dr. Mohamad El Amki, Junior Group Leader Department of Neurology, University Hospital and University of Zurich Research Focus: Our goal is to understand how blood flow dynamics are regulated in the complex of the brain vascular network in health and disease. A human brain is powered by ~650km of blood vessels which are compartmentalized into arteries, capillaries, and veins. This immensely complex network can easily fail during disease such as stroke and Alzheimer’s disease. In our projects, we focus on the regulation of blood flow through brain capillaries. Furthermore, we maintain an ongoing effort to develop novel in vitro and in vivo tools to study how to resolve obstructions in large vessels as well as in the microvasculature. We strive to find novel approaches to improve macro and microvascular function in order to keep the brain’s circulatory system functional.Keywords: Cerebral blood flow, Capillary flow, Microvascular failure, Stroke, No-reflow Topics: Biomedical Technology and Imaging, Disorders of the Nervous System, Publications: PubMed
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PD Dr. med. Jorn Fierstra, Junior Group Leader Department of Neurosurgery, University Hospital Zurich Research Focus: My research team has developed a pioneering application of blood oxygenation-level dependent (BOLD) MRI using precise vasoactive respiratory challenges in order to interrogate brain blood flow control in patients with cerebrovascular ischemic disease and malignant cerebral glioma. Since 2013, my team has built up a highly interdisciplinary international network, with special focus on cerebrovascular reactivity measurements to determine hemodynamic failure in ischemic stroke patients and to study novel concepts, such as hemodynamic brain tissue responses in chronic ischemia and stroke epiphenomena (e.g. diaschisis). In addition, for malignant cerebral glioma we are currently developing an additional BOLD contrast technique based on hypoxic tissue reactivity in order to investigate respective tissue responses of (peri-)lesional malignant cerebral glioma. The main goal is to provide new insights in the current pathophysiological concepts of blood flow control in patients with ischemic stroke and malignant cerebral glioma, thereby aiming for clinical integration of this novel advanced BOLD MRI technique for improved therapy evaluation and efficacy. Keywords: Advanced Neuroimaging, BOLD MRI, Cerebrovascular Reactivity, Cerebral Blood Flow, Cerebrovascular Autoregulation, Stroke, Cerebral Glioma, Topics: Biomedical Technology and Imaging; Disorders of the Nervous System Publications: Pubmed Website: www.neurochirurgie.usz.ch www.astranlab.com
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PD Dr. sc. Linard Filli Research Focus: Accurate movement execution is a result of a complex interplay between various muscle groups whose activity is controlled by different areas of the central nervous system (CNS). We are interested in the neural underpinnings of movement control and the neural mechanisms underlying functional recovery after spinal cord injury (SCI). Besides the corticospinal system, the phylogenetically old reticulospinal system is a key descending motor system controlling different elementary movements including posture, locomotion and reaching across vertebrate species. In contrast to the corticospinal system, there is only sparse knowledge on the role of the reticulospinal system in human motor control. One research area of interest aims at gaining more insights into the contribution of the reticulospinal system to the control of different movements (simple vs. complex, coordinative movements). Additionally, we are interested in the neuroplastic rearrangements of the main descending motor systems (i.e. cortico- and reticulospinal system) and how their neuroplastic re-weighting contributes to functional recovery in subjects with SCI. Enhanced knowledge on the plasticity and regenerative capacity of the key descending motor systems will hopefully translate into effective, future clinical trials that aim at improving motor recovery in patients with CNS injuries. Keywords: neural control of movements, locomotion, movement analysis, neurophysiology, corticospinal system, reticulospinal system, functional recovery, neuroplasticity, spinal cord injury Topics: motor systems, disorders of the nervous system Publications: PubMed Website:https://www.sci-research.uzh.ch/en.html
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Prof. Dr. Csaba Földy Research Focus: We are interested in the role of synapses in brain function. Synapses serve as fundamental sites of information transmission between neurons, with different synapses characterized by different qualities of that transmission. Frequently, these qualities are associated with the type of neurons being connected. We reason that if synaptic transmission forms the basis of information processing in the brain, and that synaptic properties can be studied in a cell-type specific manner, we will reach a deeper understanding of the brain’s information processing by performing molecular and computational analyses of synapses, as defined by their connected cell types. In pursuit of this interest, we use electrophysiology, molecular biology, and computational modeling analyses. Topics: Molecular and Cellular Neuroscience, Computation and Modeling Website: http://www.hifo.uzh.ch |
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Prof. Dr. med. Dr. rer. nat. Patrick Freund Research Focus: The focus of previous and current research projects is to better understand how the anatomy and the function of the spinal cord and the brain change in neurological disorders involving the spinal cord. The main goal is to develop neuroimaging biomarkers that are sensitive and accurate in predicting functional outcome in order to register more quickly the impact of therapeutic treatments and rehabilitative interventions. The development and application of high-resolution MR sequences and post-processing imaging pipelines are therefore a major area of our research. Other areas of interest are to explore the mechanisms underlying cortical and spinal plasticity during rehabilitation and to facilitate the translation from experimental animal models of spinal injury to humans. Keywords: spinal cord injury, neuroimaging, rehabilitation, cortical and spinal plasticity Topic: Disorders of the Nervous System Publications: PubMed Website: http://www.sci-research.uzh.ch
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Prof. Dr. Sascha Frühholz Keywords: Emotion, voice, vocal production, auditory system, limbic system Topic: Cognitive Neuroscience Publications: PubMed Website: http://www.psychology.uzh.ch |
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Dr. Katharina Gapp Lab of Molecular and Behavioral Neuroscience , Institute for Neuroscience, ETH Zurich Our research evolves around environmentally increased neuropsychiatric disease risk and the associated changes of the epigenome. We study both directly exposed mice and their offspring, which through a mode of DNA-sequence independent inheritance are often affected by parental exposures as well. The mechanism of such non-genetic effects still remains to be elucidated, but undoubtedly involves the germline. The germline is protected, to a large extent, from environmental impacts by the Weissman barrier. However, it also relies on soma-germline stress hormone signaling for proper germ cell development and function. A lot of recent work, including our own, has shown that chronic environmental challenges, such as dietary changes or chronic stressors, can change the epigenetic makeup of germ cells. However, little is known how an acute somatic signal – like for example the activation of the sympathetic nervous system – can mechanistically break the Weissmann barrier and reach the germline. We use a range of innovative technologies, including in vivo crispR cas9 (gene level), pharmacological small molecules (protein level), siRNA (RNA level) in combination with a variety of bulk, low input and single cell sequencing techniques to manipulate and analyze the epigenome and ultimately understand behaviour, metabolism and disease risk in the model organism mouse. Keywords: epigenetics, non-coding RNA, non-genetic inheritance Topic: Disorders of the nervous system, Molecular and cellular Neuroscience Publications: Google Scholar Website: https://bohaceklab.ethz.ch |
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Prof. Dr. Roger Gassert Research Focus: We apply robotics, wearable sensor technology and non-invasive neuroimaging to the exploration, assessment and restoration of sensorimotor function, with the goal of promoting recovery following neurological injury and developing assistive technologies for the compensation of remaining deficits. Keywords: physical human-machine interaction, rehabilitation robotics, haptics, assistive technology, neural control of movement, neuroimaging, neurofeedback Topics: Sensory Systems, Motor Systems, Disorders of the Nervous System, Biomedical Technology and Imaging Publications: Google Scholar Website: http://www.relab.ethz.ch
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Prof. Dr. Nathalie Giroud Research Focus: In our group we investigate mechanisms of language processing in the brain using a variety of neuroimaging techniques (e.g. EEG, MRI) as well as psychophysical and neuropsychological testing. Our research focuses on the neural underpinnings of the highly prevalent age-related hearing loss and speech perception difficulties in older adults. We are working towards understanding its impact on the brain and its relationship with cognitive decline in healthy individuals and in older adults with neuropathology such as Alzheimer’s disease. The long-term goal of our research is to develop rehabilitation strategies for audio(-visual) speech processing difficulties in healthy older adults and individuals with mild cognitive impairment and dementia. Furthermore, we are also interested in understanding the association between hearing loss and brain atrophy, cognitive mechanisms of audiovisual speech processing, as well as bilingualism and foreign language learning in an aging population. Keywords: hearing loss, aging, dementia, language, speech processing, neural entrainment, EEG, MRI, audiovisual processing, cognition Topics: Cognitive Neuroscience, Sensory Systems Publications: Google Scholar Website: https://www.cl.uzh.ch
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Prof. Dr. Melanie Greter Research Focus: The mononuclear phagocyte system (MPS) is defined as a group of myeloid cells comprised of monocytes, macrophages and dendritic cells. The different members of the MPS display substantial heterogeneity in terms of ontogeny, turnover and functional properties during homeostasis and inflammation. Our goal is to identify key molecules necessary for the development and function of the MPS. We will focus on microglia, a specialized brain-resident macrophage population. We aim to discover new lineage guiding transcription factors involved in microglia regulation. In addition, we will generate new mouse strains in order to specifically target microglia in vivo and to genetically manipulate CNS-invading monocytes during neuroinflammation. Keywords: Microglia, macrophages, cytokines, development, neuroinflammation Topic: Neuroimmunology Publications: PubMed Website: http://www.immunology.uzh.ch
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Prof. Dr. Benjamin F. Grewe Research Focus: My primary research focus is directed towards understanding the basis of information processing and memory formation in neuronal networks using experimental as well as computational approaches. Currently my research at the INI investigates basic concepts of information processing and memory formation in limbic neuronal networks, using miniaturized cutting-edge imaging techniques to record learning induced changes in neuronal network activity of mice. Aligning with the combined strengths of the INI and in collaboration biomedical and electrical engineering groups my long-term vision is to extract fundamental principles of network-learning from real biological networks and then to reverse engineer their functionality as logical, reproducible algorithms that be implemented in software or directly as electrical circuits. I am convinced that reverse-engineering neural learning algorithms that mimic human thinking will one day change the importance of intelligent technologies in our everyday life Keywords: systems and computational neuroscience, population coding, neuronal network learning, deep learning, spiking network simulations, calcium imaging, two photon microscopy, miniaturized microscope, freely moving, behavior Topic: neural basis of behavior, computation and modeling, sensory systems Projects: https://www.ini.uzh.ch Publications: PubMed Website: https://www.ini.uzh.ch
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Prof. Dr. Christian Grimm Research Focus: Although many patients worldwide suffer from retinal degenerations, there are currently no therapies for the successful treatment of most blinding diseases of the retina. Our work focuses on biochemical events and signaling cascades during retinal degenerations. The goal is to understand the molecular pathways induced by the disease-causing stimuli to develop strategies (neuroprotection, gene therapy) which may ultimately rescue vision in patients. Current projects focus i) on intercellular signaling with special emphasis on the interaction between photoreceptors and Müller glia cells; ii) on leukemia inhibitory factor (LIF) with respect to its potential function as modulator of stem cell-like properties of Müller cells; iii) on the analysis of cone pathophysiology using a newly developed ‘all-cone mouse’; and iv) on acute and chronic hypoxia as potent modulators of photoreceptor survival and degeneration, respectively. Keywords: Retinal degeneration, hypoxia, leukemia inhibitory factor, retina, blindness, cones, neuroprotection, gene therapy Topics: Sensory Systems; Molecular and Cellular Neuroscience, Disorders of the Nervous System Publications: https://www.lrcb.uzh.ch Website: https://www.lrcb.uzh.ch
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Prof. Dr. Edna Grünblatt Research Focus: We are interested in finding risk factors and biomarkers for child and adolescent psychiatric disorders such as attention-deficit hyperactivity disorder (ADHD), early-onset obsessive-compulsive disorder (OCD), Autism spectrum disorders (ASD), psychosis and environmental /stress effects. In addition, the laboratory focuses on functional mechanisms of action of gene variants found to associate to a specific disorder as well as mechanism of action of drug therapies in various neuronal cellular models. Since psychiatric disorders are not only polygenetic predisposed but also influenced by environmental factors, epigenetic is another factor investigated in the lab. This could provide additional tools for early and differential diagnosis as well as therapy prediction. Keywords: ADHD, ASD, biochemistry, child and adolescent psychiatry, epigenetic, genetic, molecular biology, neurodevelopmental disorders, neuronal cellular models, OCD, psychosis, transcriptomics Topics: Development and Regeneration, Disorders of the Nervous System, Molecular and Cellular Neuroscience Publications: PubMed Website:https://www.kjpd.uzh.ch |
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Prof. Dr. Johannes Häberle Department of Pediatrics, Division of Metabolism, University Children’s Hospital and Children’s Research Center Zurich, Zurich johannes.haeberle@kispi.uzh.ch Research Focus: Hyperammonemia is a clinical condition that can be caused by defects (in a primary or secondary way) of the urea cycle, the only pathway in mammalians capable of detoxification of excess nitrogen. Current research projects focus on inherited defects of the urea cycle including novel treatment options, and on several other conditions with hyperammonemia. Keywords: Hyperammonemia, urea cycle, nitrogen metabolism, brain edema Topic: Disorders of the Nervous System Publications: PubMed Website: http://www.kispi.uzh.ch
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Prof. Dr. Richard Hahnloser Research Focus: We research sensorimotor and observational learning, birdsong development, neural coding in auditory and motor brain areas, ultrastructure of synaptic networks. We make use mainly of computational modeling, behavioral methods, electrophysiology, and light- and electron microscopy. Keywords: imitation behavior, learning Topics: Computation and Modeling, Neural Basis of Behavior, Motor Systems Publications: https://www.ini.uzh.ch/publications Website: https://www.ini.uzh.ch
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Prof. Dr. Todd Hare Research Focus: Decision making is central to human behavior and the ability to make good choices is necessary for personal health and optimal social functioning. Our goal is to understand the neural mechanisms of decision making in healthy, typical populations as well as how these processes become dysfunctional in specific behavioral disorders and pathophysiologies. We examine the neural networks that mediate decision making for various reward types (primary, monetary, social), and have shown that while key areas of the decision network are recruited across choice domains, the regions with which they interact differ between decision contexts. Using a combination of behavioral, neuroimaging, brain stimulation, and computational modeling techniques, current projects focus on the impact of factors such as stress, social feedback, and attention on both self-control and normative decision making. Keywords: decision making, self-control, strategic choice Topic: Cognitive Neuroscience Publications: http://www.econ.uzh.ch Website: https://www.econ.uzh.ch
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Prof. Dr. Fritjof Helmchen Research Focus: Acting in the world means using the power of the neural circuits in your brain. But how do these complex circuits, comprising diverse neuronal and glial cell types interconnected in a highly complicated fashion, actually operate? How do they process sensory stimuli, integrate sensory information with relevant context and past experiences, and how do they produce motor control signals for adequate behavior? Newest technical developments, especially optical methods and genetic tools to record from and manipulate identified neural circuit components, down to individual neurons, now make it possible to tackle these fundamental questions. We develop and apply 2-photon microscopy and fiber-optic tools to gain understanding of the principles of signal flow in local neural circuits as well as the larger networks of brain regions. In ongoing projects we apply these methods in behaving mice to reveal neural dynamics underlying various behaviors. Keywords: Neural networks, in vivo physiology, optical imaging, electrophysiology, goal-directed behavior Topic: Neural Basis of Behavior Publications: http://www.hifo.uzh.ch Website: http://www.hifo.uzh.ch
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Prof. Dr. Katharina Henke Research Focus: Our neuroimaging findings suggest that the human hippocampal formation specializes in the rapid establishment of new associations between items in memory. Patient studies revealed that the hippocampal formation is necessary for the rapid encoding and retrieval of new associations even when encoding and retrieval were carried out unconsciously. We found a role of sleep in the consolidation of consciously and unconsciously acquired memories. Even de-novo memory formation during daytime naps appears feasible. We currently test for a potential advantage of unconscious over conscious information processing in situations where complex information needs to be simultaneously processed and integrated. This research informs models of information processing and models of memory systems at both the neural and mental level. Keywords: Human memory, unconscious information processing, hippocampus, sleep, neuroimaging Topic: Cognitive Neuroscience Publications: https://www.boris.unibe.ch Website: http://www.apn.psy.unibe.ch
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Prof. Dr. Alexis Hervais-Adelman Research Focus: Our research centres on the neural basis of language. In particular we focus on speech perception, multilingualism and literacy. We employ a variety of techniques including structural and functional MRI, EEG, MEG, tES and behavioural experiments combined with novel analyses to characterise the brain networks crucial to language, and their relationships with other cognitive faculties. We are particularly interested in using our fundamental research program to contribute developing interventions that can help support speech comprehension for individuals suffering from hearing impairment. Keywords: Speech, Language, Neuroimaging, Multilingualism, Motor System, Basal Ganglia Publications: Google Scholar Website: https://www.psychology.uzh.ch/en/areas/nec/neulin.html
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Prof. Dr. Christoph Hock
Topic: Disorders of the Nervous System Websites: http://www.irem.uzh.ch
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Prof. Dr. med. univ. Philipp Homan Research Focus: We study the neurobiological origins and clinical consequences of individual differences in psychotic disorders. Specifically, we are interested in understanding those subgroups of patients who respond unfavorably to standard treatment and for whom alternative treatment options early in their course of illness are warranted. Another subgroup that we are particularly interested in are patients who might benefit from an early dose reduction of antipsychotic treatment after their first episode of psychosis. To this end, we combine randomized clinical trials with multimodal neuroimaging including structural and functional imaging as well as computational modeling to characterize those subgroups and to develop predictive models that will contribute to a more stratified medicine in psychiatry. |
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PD Dr. sc. nat. Simone Hornemann Research Focus: We are interested in the understanding of the molecular mechanisms of protein misfolding and aggregation diseases, such as e.g. prion, Parkinson’s and Alzheimer disease. Our main goal is to clarify whether common mechanisms underlie all those diseases and ultimately to develop new diagnostic and therapeutic strategies. Keywords: Neurodegenerative diseases, protein self-assembly, amyloid fibrils, amyloid structure, high-throughput screenings, diagnostic assay development, therapy Topic: Disorders of the Nervous System Publications: PubMed Website: https://www.usz.ch/team/simone-hornemann/
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Prof. Dr. Thorsten Hornemann
Topic: Disorders of the Nervous System Website: http://www.ikc.usz.ch |
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Prof. Dr. med. Alexander Huber Research Focus: In our laboratory for biomechanics of hearing we develop a comprehensive understanding and a detailed theoretical model of the physiological and pathological processes of the peripheral auditory system (from the pinna to the auditory nerve). The objectives are 1) Experimental studies of physiological and pathological processes of hearing, 2) The development of a detailed mathematical model of hearing, and 3) The optimization and development of hearing aids and hearing prostheses in collaboration with the industry. We are an interdisciplinary research team of graduates from different specialties, with competence in investigation techniques of acoustics, vibro-mechanics, fluid dynamics, electrophysiology and behavioral audiometry by taking into account the latest measurement technology. Keywords: Hearing, Biomechanics, Implants Topics: Sensory Systems, Biomedical Technology and Imaging Website: https://www.usz.ch
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Prof. Dr. Reto Huber Research Focus: Sleep wake regulatory mechanisms seem to be casually related to cortical plasticity. More specifically, wakefulness favours synaptic strengthening or synapse formation. On the other hand, sleep, in particular deep sleep, promotes synaptic weakening or synapse elimination, ensuring synaptic homeostasis. Cortical plasticity plays a key role for brain maturation. A large body of evidence indicates that aberrations in the trajectory of cortical plasticity are linked to the development of psychiatric disorders. We investigate mechanism underlying the interplay between sleep and wakefulness and how such mechanisms may impact the remodelling of cortical circuits during development and therefore might be related to the susceptibility of psychopathology. Keywords: sleep regulation, cortical maturation, synaptic plasticity, high-density EEG, MRI, closed-loop stimulation Topics: Sleep and Sleep Disorders, Development Publications: PubMed Websites: https://www.kispi.uzh.ch
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Dr. Michèle Hubli Research Focus: Our primary research interest lies in the field of maladaptive neuroplastic changes after neurological trauma, such as spinal cord injury (SCI). Employing a variety of neurophysiological and autonomic assessments such maladaptive changes within the somatosensory system, i.e., the development of neuropathic pain, as well as the autonomic nervous system are investigated in human SCI. Current projects in the lab focus on i) sensory-autonomic interaction using contact-heat and sympathetic skin responses; ii) temporal summation of pain and conditioned pain modulation; iii) multi-modal electrophysiology of the spinothalamic tract. Consolidated mechanistic understanding of the sensory and autonomic plasticity is highly relevant in the process of evaluation and design of novel therapeutic interventions in human SCI and the stratification of patients for clinical trials. Keywords: clinical neurophysiology, neuropathic pain, spinal reflexes, autonomic nervous system, spinal cord injury Topics: Sensory System, Disorders of the Nervous System Publications: PubMed Websites: https://www.sci-research.uzh.ch
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Dr. med. MSc. Michael Hugelshofer Department of Neurosurgery, University Hospital and University of Zurich Michael.Hugelshofer@usz.ch Research Focus: As a neurosurgeon-scientist my research focuses on the complex pathophysiology of secondary brain injury after hemorrhagic stroke with the aim to develop new diagnostic and therapeutic strategies. Since 2016, we have established an interdisciplinary scientific network to investigate the toxicity of cell-free hemoglobin in the brain. We were able to define delocalization of hemoglobin from the CSF into cerebrovascular vessel walls and the interstitial space of the brain as the pivotal step for hemoglobin’s toxic effects. Further we could proof the concept of intracerebroventricular haptoglobin treatment to compartmentalize and detoxify hemoglobin within the CSF compartment in translational animal models. Our current projects focus on bench-to-bedside translation of this knowledge to diagnostic and therapeutic clinical applications. Keywords: hemorrhagic stroke, hemoglobin, haptoglobin, secondary brain injury, neuroprotection, translational neuroscience, neurosurgery Topics: Disorders of the Nervous System; Biomedical Technology and Imaging Websites: https://www.usz.ch https://primelab.ch/ |
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PD Dr. med. Lukas Imbach Research Focus: We study the neurophysiological underpinnings of epilepsy in humans. A special research focus lies on network properties of epileptogenesis at different scales. On the smallest scale, we explore network alterations in micro circuitries of single neurons within the epileptogenic zone. On the other end of the spectrum, we investigate large-scale network dynamics involved in seizure propagation and their evolution comprising widespread brain regions. To this end, we study scalp EEG, intracranial EEG, single unit activity and EEG source imaging in combination with theory-based models of brain connectivity. The key insights are used to derive novel biomarkers of epilepsy and to modulate imbalanced epileptic network states by means of invasive and non-invasive brain stimulation technics such as deep brain stimulation (DBS) and transcranial direct current stimulation (tDCS). Other areas of interest include single neuron activity obtained in intracranial EEGs to study basic neurobiological mechanisms of cognitive functions. |
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Prof. Dr. Giacomo Indiveri Research Focus: Our research concerns the analysis and development of computational models, hybrid analog/digital VLSI circuits, and multi-chip event-based systems for implementing real-time distributed neural processing systems, and eventually building Neuromorphic Cognitive Systems (i.e. neuromorphic architectures that can learn and reason about the actions to take, in response to the combinations of external stimuli, internal states, and behavioral objectives). The neuromorphic cognitive systems we develop are typically real-time behaving systems comprising multi-chip, multi-purpose spiking neural architectures. They are used to validate brain inspired computational paradigms in real-world scenarios, and to develop a new generation of fault-tolerant event-based computing technologies. Keywords: Neuromorphic, learning, plasticity, attention, electronic circuits Topic: Computation and Modeling Publications:Google Scholar Website: https://ee.ethz.ch |
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PD Dr. Dr. med. Andras Jakab Keywords: magnetic resonance imaging, brain development, fetal development, image processing Topics: Disorders of the Nervous System, Biomedical Technology and Imaging Publications: Google Scholar Website: https://www.kispi.uzh.ch
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Prof. Dr. Sebastian Jessberger Research Focus: New neurons are continuously generated in two discrete areas of the adult brain – the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Our group is interested in the underlying biology of adult neurogenesis, including the fate plasticity of adult neural stem cells (NSCs) and the molecular mechanisms governing stem cell activity and neuronal integration. Currently, we use gene expression profiling together with analyses of the metabolic state of NSCs and their progeny to study the molecular framework of NSC diversity in the adult brain and to identify novel regulators of the neurogenic process. In addition, our laboratory aims to understand how physiologic and disease-associated alterations of the neurogenic niche are translated into stem cell-associated plastic changes of the adult brain on a cellular but also behavioral level. Keywords: Neural stem cells, hippocampus, ageing Topic: Development and Regeneration Publications: http://www.hifo.uzh.ch Website: http://www.hifo.uzh.ch
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Dr. sc. Jingjing Jiang, Junior Group Leader Research Focus: Non-invasive neuroimaging is crucially needed for examining functional brain activities for researchers and clinicians. My research interests lie in the area of biomedical imaging, specifically tomography using near infrared light. This technique detects changes in parameters relevant to brain function non-invasively. Keywords: Near infrared optical tomography, brain imaging, time of flight imaging Topic: Biomedical Technology and Imaging Publications: Google Scholar
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Prof. Dr. rer. nat. Hennric Jokeit Research Focus: Temporal lobe epilepsy is the most prevalent form of refractory focal epilepsy. Functional and structural impairment within and remote from mesial temporal lobe structures characterize this chronic disorder. Deficits in anterograde episodic memory, executive and attention functions, and social cognition are frequent in patients with mesial temporal lobe epilepsies. Our primary research focus is on less well studied deficits in social cognition using behavioral testing, functional, and structural magnetic resonance imaging. Moreover, we develop and validate fMRI paradigms to activate reliably specific target structures in individual patients in order to improve the presurgical workup of patients who are candidates for epilepsy surgery. Keywords: epilesy, epilepsy surgery, temporal lobe, memory, affective and social cognition, fMRI Topic: Disorders of the Nervous System Publications: PubMed Website: http://www.kliniklengg.ch |
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Prof. Dr. Catherine Jutzeler Catherine.Jutzeler@hest.ethz.ch Research Focus: The Biomedical Data Science Lab (BMDS) is an interdisciplinary, motivated, young research team working at the intersection of medicine, data science, and biology. Our research aims to identify causes, risk factors, and biomarkers of disease progression. At the core of our research is a series of prospective and retrospective investigations that integrate genetic, biochemical, clinical assessments, and medication history with both traditional epidemiological approaches and machine-learning algorithms. Currently, we are doing research in the fields of spinal cord injury, lower back pain, and infectious diseases (e.g., sepsis in children and adults). In addition to research, we are involved in teaching activities. The major goal is to provide the students with an introduction to applied data science (programming, analysis, visualization) to solve biomedical questions. |
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Prof. Dr. Theofanis Karayannis Research Focus: The brain begins to form during embryogenesis, but undergoes a protracted period of development that lasts into adulthood. Our work is aimed at understanding how the environment moulds the construction and reconfiguration of neuronal circuits to allow them to effectively process and respond to external stimuli throughout development. The goal is to unravel how the interplay between electrical activity and genetic programs controls the assembly and plasticity of cortical circuits that are involved in processing and gating sensory information. To achieve this, we utilize a multi-dimensional approach that includes molecular, genetic and functional methods. It is our hope that this research will not only provide insights into the making of the healthy brain, but also into neurodevelopmental brain pathologies resulting from aberrant circuit wiring. Topics: Development and Regeneration, Sensory Systems, Disorders of the Nervous System, Molecular and Cellular Neuroscience, Neural Basis of Behavior Website: http://www.hifo.uzh.ch |
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Dr. phil. Iliana I. Karipidis, Junior Group Leader Research focus: We use pediatric neuroimaging techniques (MRI and EGG) to understand the neurobiological mechanisms underlying sex and gender differences in specific learning disorders and psychiatric disorders that emerge during childhood and adolescence. One of my current projects focuses on understanding the effects of sex steroids on reward processing during puberty. In collaboration with the Hong Lab at Stanford University, we examine effects of gender-affirming hormone therapy on neurodevelopment in transgender youth. The goal of this research is to increase our understanding of transgender health, promote well-being in gender minority youth, and enable the integration of evidence about sex and gender differences into clinical practice of child and adolescent psychiatry. Keywords: pediatric neuroimaging, reading acquisition, specific learning disorders, gender identity, sex differences Topics: Cognitive Neuroscience, Neural Basis of Behavior Publications: Google Scholar Website: https://www.kjpd.uzh.ch/de/multimod/neuroimaging/team/karipidis.html
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PD Dr. med. MSc Mira Katan Kahles Department of Neurology, University Hospital Zurich mira.katan@usz.ch Research Focus: To identify (using OMICS-methods) and validate (conducting clinical studies and trials) prognostic and diagnostic blood biomarkers to improve risk stratification and clinical decision-making in cerebrovascular diseases. The ultimate goal is to optimize patient care and improve outcome as well as allocation of health care resources. Keywords: Stroke, blood biomarkers, clinical decision making, outcome research Topic: Disorders of the Nervous System Publications: PubMed Website: http://www.stroke.usz.ch
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Dr. Annika Keller Research Focus: We are elucidating molecular mechanisms by which vascular dysfunction in the CNS leads to neuroinflammation and neurodegeneration. Keywords: blood-brain barrier, pericytes, endothelium, neuroinflammation, microvessel calcification Topic: Molecular and Cellular Neuroscience Publications: PubMed Website: https://akellerlab.ch
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Prof. Dr. med. Emanuela Keller Research Focus:
Keywords: Multi-modal monitoring, cerebral hemodynamics, optical spectroscopy, stroke, subarachnoid hemorrhage Topic: Disorders of the Nervous System Publications: PubMed Website: http://www.intensivmedizin.usz.ch
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Prof Dr. med. Thomas M. Kessler Research Focus: Neurogenic urinary tract, sexual and bowel dysfunction is highly prevalent and affects the lives of millions of people worldwide. Current projects focus on new assessments (neurophysiology, neuroimaging) of urinary tract function, novel methods to control urinary tract infections, electrotherapy for treating neurogenic urinary tract dysfunction, translational research (from animal models to daily clinical practice), and systematic reviews and meta-analyses in neuro-urology. Keywords: Neuro-urology, urinary tract dysfunction, sexual dysfunction, bowel dysfunction, urodynamics, neuro-urological assessments and therapies, translational research Topic: Disorders of the Nervous System Publications: PubMed Websites: https://www.balgrist.ch/ https://www.swisscontinencefoundation.ch/
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Dr. Sanne Kikkert Neural Control of Movement Lab, ETH Zurich Research Focus: The ability to sense through touch is fundamental to actively interact with our environment. If we lose such sensory information through injury (e.g., spinal cord injury or limb loss), our brains are deprived of a major source of input, and we are required to use novel motor strategies. My team’s research aims at exploring how human brains are affected by such changes, what neural mechanisms may underlie resulting neural reorganisation, and how the human brain responds to sensory reinstatement through neuroprosthetics. A large body of our research focuses on exploring the brainstem as a key hub in brain plasticity, a structure that has been largely overlooked in human brain plasticity research. To do so, we merge cutting-edge functional and structural neuroimaging techniques. Our findings are expected to provide fundamental insights into human brain plasticity that may ultimately be used to guide desirable plasticity, discourage maladaptive plasticity, and better tailor treatments based on individual differences.
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Prof. Dr. Daniel C. Kiper Research Focus: I am interested in the treatment of visual signals in the neocortex, on the effects of virtual reality on cortical processing, and in the ways virtual reality can be used to help neurological patients. I use primarily psychophysical and imaging techniques to probe the cortical processes underlying vision as well as those supporting plasticity in the injured brain. In addition, I develop outreach programs within the Lifescience Zurich Learning Center to promote modern biology within the swiss public school system. Keywords: Colour vision, Psychophysics, Visual Cortex, Science education Topic: Sensory Systems Publications: PubMed Website: https://www.ini.uzh.ch
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Prof. Dr. Birgit Kleim Psychiatric University Hospital (PUK)
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Prof. Dr. Tobias Kleinjung Department of Otorhinolaryngology, University Hospital Zurich Research Focus: Tinnitus is defined as a perception of sound without any external sound source. Tinnitus is triggered by peripheral, mainly inner ear hearing loss, but the most essential changes in terms of tinnitus development take place in the central nervous system. Due to the difficult and individual pathophysiology od tinnitus no causal cure for tinnitus has been documented so far. Most pharmacologic and psychosomatic treatment modalities aim at improving tinnitus related impact on the quality of life. Our main focus is clinical research in the field of tinnitus, hearing loss and auditory neuroplasticity. The key aspect is the search for novel treatment modalities of tinnitus and inner ear hearing loss. In terms of tinnitus the research group is engaged in the investigation of different type of neuromodulation approaches like neurofeedback and transcranial electrical brain stimulation. Furthermore, we are interested in the improvement of tinnitus subtyping. This includes the evaluation of new psychometric measurements as well as identifying of tinnitus related neuroplastic changes in the brain by EEG, MRI and PET recordings. Keywords: tinnitus, hearing loss, auditory system, neuroplasticity Topic: Sensory Systems Publications: PubMed Websites: https://www.tinnitus.uzh.ch
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Dr. rer. nat. Uwe Konietzko Research Focus: The amyloid precursor protein (APP) is central to Alzheimer’s disease (AD). Multiple proteolytic cleavages generate several APP fragments, including the APP intracellular domain (AICD). We could show that AICD translocates to the nucleus, bound to the adaptor protein Fe65. Here, they co-localize in nuclear spots together with the lysine acetyltransferase Tip60, at the loci of regulated genes. APP thus has the capacity for nuclear signaling and we have demonstrated that this property is mediated by the amyloidogenic—disease-causing—cleavage pathway of APP. Altered AICD nuclear signaling could therefore be involved in the molecular cascades leading to neuronal death in AD. We are now striving to better understand the regulation of AICD signaling and to identify target genes that will inform us about the probable effects on synapses and that might represent novel therapeutic targets to prevent synapse loss and neuronal death in AD. Keywords: Alzheimer’s disease, amyloid precursor protein APP, AICD, Fe65, nuclear signaling Topic: Disorders of the Nervous System Publications: PubMed Website: http://www.irem.uzh.ch
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PD Dr. sc. nat. Karin Kucian, Junior Group Leader Research Focus: Our research interests in neuroscience lie in developmental neuropsychology, in particular with emphasis on neuronal correlates of number processing and calculation in children and the effects of specific learning disorders, like developmental dyscalculia, or math anxiety on brain structure and function. Based on our own findings from behavioural and brain imaging studies (magnetic resonance imaging) and current knowledge about number processing and calculation we are also involved in the development and evaluation of special interventions for children with mathematical learning problems. Keywords: number processing, dyscalculia, calculation, development, children, intervention, brain imaging, MRI Topic: Cognitive Neuroscience Publications: PubMed Website: https://www.kispi.uzh.ch
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Prof. Dr. Vartan Kurtcuoglu Research Focus: My group’s goal is to address clinical needs through the convergence of engineering, biological and medical research. Within the neuroscience field, we focus on transport processes in the fluid spaces of the brain, namely in the cerebrospinal, interstitial and perivascular fluids. By combining computational techniques with experimental methods, we aim to understand the dynamics of cerebral fluid motion, the driving forces behind these and how they, along with the associated transport processes of metabolites and other substances, are involved in the pathogenesis of CNS disorders Keywords: volume transmission, fluid dynamics, hydrocephalus, astrocyte network, mechanosensing Topic: Computation and Modeling, Biomedical Technology and Imaging, Disorders of the Nervous System Publications: http://interfacegroup.ch Website: http://interfacegroup.ch |
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Dr. sc. nat. Salome Kurth, Junior Group Leader Research Focus: Across the first years of life the human brain experiences its greatest anatomical and functional modifications. These are closely reflected in the electroencephalogram (EEG) recorded during sleep. We increasingly understand how these neuronal maturation processes are linked to sleep behavior. It is still unclear however, i) which parameters of infant sleep behavior represent a health risk for neurodevelopment and ii) whether early sleep patterns are a trait and thus persist throughout later life. Further, iii) associations between sleep and the gut bacteria remain understudied. Gut bacteria are increasingly recognized as a health marker, they evolve rapidly throughout the first months of life and seem to be linked to brain plasticity and behavior. Supported by the Swiss National Science Foundation, Sleep and Health, the Medical Faculty and the Forschungskredit at the University of Zurich as wll as the Olga Mayenfisch Stiftung and the Stiftung für Wissenschaftliche Forschung, we investigate the development of sleep across early human life. We examine interactions with brain activity, physiology, including gut bacteria and family context. We employ population-based measures, high spatial resolution EEG during sleep and behavioral testing. We hope to improve understanding of the sleep-related risk factors for neurodevelopment and to identify predictors of brain connectivity and behavioral outcome. It is our vision that the identification of sleep-related risks in early life finds translation into novel approaches to reduce developmental disorders and ultimately improve mental health. Keywords: Sleep during infancy and early childhood, sleep regulation, brain connectivity, neurodevelopment, gut bacteria, EEG, MRI Topics: Sleep and Sleep Disorders Publications: Google Scholar PubMed Website: www.sleep.uzh.ch |
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Dr. Marie Labouesse Department of Health Sciences and Technology, ETH Zurich Research Focus: Our team strives to understand how long-range neural circuits wire and rewire throughout the lifespan, how they contribute to behavioral function, and how we can harness new, circuit-related findings to develop pharmacotherapies to treat brain disorders. Our work focuses on the basal ganglia and their inputs and outputs (including monoamines, like dopamine), with a special interest for neural systems critical for body homeostasis, e.g. brain circuits for reward and energy seeking (motivation, feeding, addiction) and for energy output (locomotion, motor function, exercise). Through this work, we hope to contribute a deeper understanding of the postnatal ontogeny and adult plasticity of basal ganglia circuits. We also aim at developing and screening targeted therapeutic approaches to treat basal ganglia and dopamine related brain disorders. This includes illnesses such as mood disorders, eating disorders, addiction, obesity or Parkinson’s disease. Keywords: wiring, experience, neural circuits, basal ganglia, behavior, optical tools, in vivo fluorescent imaging, biosensors, pharmacotherapy, neuropharmacology, transgenic models. Topics: Neural Basis of Behavior, Development and Regeneration Publications: Google Scholar Websites: https://labouesse.wixsite.com
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Dr. Olivier Lambercy Rehabilitation Engineering Lab, Dep. of Health Sciences and Technology, ETH Zürich Research Focus: In our group we are developing and clinically evaluating novel technologies to support the assessment and therapy of upper limb function in people with neurological disorders (stroke, SCI, multiple sclerosis). In particular, we are interested in using movement data (kinematic and kinetic) to derive more objective and sensitive health metrics that can help understand impairment mechanisms (in human and animal models), finely quantify functional limitations and response to therapy interventions, and develop predictive models to personalize rehabilitative treatments. Keywords: Technology-based assessments, wearable sensors, robotics, neurorehabilitation, digital health, biomarkers Topic: Sensory Systems, Motor System, Disorders of the Nervous System Publications: scholar.google.ch Website: http://www.relab.ethz.ch
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Prof. Dr. sc. nat. Hans Peter Landolt Institute of Pharmacology and Toxicology, University of Zürich Research Focus: Sleep enables the brain to optimize higher cognitive functions such as learning and memory. My group focuses on the pre-clinical human neuropsychopharmacogenetics of CNS stimulants and hypnotics, and the neurochemical underpinnings of wakefulness and sleep. Along a molecule-to-human-to-medicine continuum, it aims at elucidating basic genetic and molecular mechanisms underlying sleep-related brain functions. Our research employs specific pharmacology, electro-encephalography, genotyping, brain imaging and neurocognitive testing to investigate the roles for neuromodulators, receptors and transporters in regulating sleep-associated waking functions. It is our vision that a basic understanding of the neurobiological mechanisms underlying the detrimental and beneficial (i.e., antidepressant) effects of sleep loss will be translated into novel therapies that will improve brain functioning, general well-being, quality of life, and public health. Keywords: Sleep-associated attentional, affective, and cognitive processes; individual vulnerability to sleep deprivation; disease- and age-related changes in sleep-associated brain functions Topic: Sleep and Sleep Disorders, Neural Basis of Behavior Publications: PubMed Website: https://www.pharma.uzh.ch/
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Prof. Dr. Nicolas Langer Research Focus: Our lab develops and obtains new neurophysiological and neuroimaging measures in the context of human brain and behavioral plasticity. Specifically, we investigate the potential for plasticity, mechanisms for stabilization and compensation across the lifespan. In particular, we investigate the relationship between brain plasticity and cognitive functioning, such as perceptual processing, learning, (working-) memory, decision-making and processing speed. Topics: Cognitive Neuroscience, Computation and Modeling, Neural Basis of Behavior, Development and Regeneration Publications: Google Scholar Website: http://www.psychologie.uzh.ch
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Prof. Dr. Shih-Chii Liu Keywords: neuromorphic sensor, cochlea, networks, deep spiking networks, auditory systems, spike coding, Topic: Computation and Modeling, Sensory Systems Publications: http://sensors.ini.uzh.ch Website: https://www.ini.uzh.ch
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Prof. Andreas Luft Research Focus: Despite the effectiveness of acute stroke therapies, up to 80% of stroke patients are left disabled due to motor, speech, visual or cognitive impairment. With more than 16’000 new strokes happening in Switzerland every year and an aging population, neurorehabilitation is becoming ever more important. Keywords: stroke, functional recovery, neuroplasticity, motor learning Topic: Disorders of the Nervous System Publications:PubMed Website: https://www.usz.ch
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Dr. Caroline Lustenberger Research Focus: Identifying strategies to promote healthy ageing has gained considerable interest. Sleep represents a fundamental restorative process and is essential for our health. With increasing age, sleep quality can be greatly reduced and thus restorative processes less pronounced suggesting it to be a prime target to promote healthy ageing. Yet, efficient sleep interventions that can promote recovery processes of brain and body to promote the health span are not established because scientific insights in the causal role of specific sleep processes in these recovery processes are missing. My team’s research aims at identifying the role of brain activity during sleep in recovery processes of brain and body from young to old age. To do so, we will merge cutting-edge non-invasive (closed-loop) brain stimulation techniques to modulate sleep oscillations with advanced body (e.g. cardiovascular, metabolic) and brain assessments (e.g. EEG, cognitive functions) to delineate the causal role of sleep oscillations in these functions. Our findings might proof transformative for maintaining health up until old age and open completely new opportunities for modulating regenerative processes across the brain and body. Keywords: sleep oscillations, high-density EEG, non-invasive closed-loop stimulation, memory consolidation, cognition, ageing, cardiovascular function and health, metabolic function and health, restoration Topic: Sleep and sleep disorders, Cognitive Neuroscience Publications: Google Scholar Website: https://ncm.hest.ethz.ch |
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Prof. Dr. Thomas A. Lutz Research Focus: The two main research areas are the control of food intake, including the pathophysiology of obesity and type 2 diabetes mellitus. Keywords: Amylin, Leptin, Cytokines, Hypothalamus, Bariatric surgery, Type 2 diabetes mellitus Topic: Neural Basis of Behavior Website: http://www.vetphys.uzh.ch |
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Prof. Dr. Isabelle Mansuy Research Focus: The laboratory is interested in the epigenetic basis of complex brain functions and their inheritance. With a focus on childhood trauma, we are studying the molecular and cellular mechanisms underlying the influence of life experiences on mental and physical health across generations. We developed a transgenerational mouse model of postnatal trauma, and are investigating epigenetic processes at the level of DNA, RNA and protein in whole tissues and individual cells including brain and germ cells. DNA methylation, small and long non-coding RNA, chromatin structure and accessibility and their causal relevance for the expression and the transmission of trauma symptoms are examined. The major goal is to clarify the functional interplay between the genome and epigenome in the inheritance of environmentally-induced phenotypes. We also conduct translational studies on blood, saliva and sperm of human subjects exposed to childhood trauma in collaboration with clinicians and psychiatrists to validate findings in mice, and explore the potential for diagnostic and therapeutic strategies based on epigenetic factors. Keywords: Epigenetics inheritance, childhood trauma, mouse model, brain, germ cells, multi-omics, RNA-seq, bisulfite pyrosequencing, ATAC-seq, ChIP-seq, CRISPR-dCas9, 3D cellular models, behavior, bioinformatics, psychiatry. Topic: Molecular and Cellular Neuroscience, Disorders of the Nervous System, Neural Basis of Behavior Publications: PubMed Website: https://www.hifo.uzh.ch
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Prof. Dr. Valerio Mante
Topic: Sensory Systems Website: https://www.ini.uzh.ch
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Prof. Dr. Mike Martin Website: https://www.psychologie.uzh.ch
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Prof. Dr. med. Roland Martin Research Focus: The focus of our research is to understand better the disease heterogeneity of Multiple Sclersosis using imaging techniques (MRI and optical coherence tomography, OCT), biological markers and motor function. In the laboratory we examine disease mechanisms of MS with particular focus on cellular immunology and biochemistry. We strive at developing new treatments particularly in areas of unmet medical needs of MS such as neuroprotection, induction of tolerance and regenerative therapies. Keywords: Multiple sclerosis, T cell, antigen-specific tolerization, progressive multifocal leukoencephalopathy, experimental therapy Topic: Neuroimmunology Publications: PubMed Website: https://www.usz.ch http://www.multiplesclerosis.uzh.ch
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PD Dr. Michael L. Meier Research Focus: People move differently in the presence of (or in anticipation of) pain. Changes in motor control may play an important role in musculoskeletal pain. In our laboratory, we use an interdisciplinary approach that combines neuroscience and movement biomechanics research to provide new insights into the role of possible interactions between motor control and psychological factors in the development and maintenance of low back pain. The methodological basis includes the assessment of psychological factors, biomechanical assessments of movement during functional activities based on high-resolution optical motion capture and musculoskeletal modeling, and generation of cortical topographic maps of paraspinal afferent input using functional magnetic resonance imaging (fMRI). Ultimately, this cross-disciplinary approach might lead to a better understanding of low back pain with the potential to translate into clinical research for better treatment options. Keywords: low back pain, pain-related fear, spine kinematics, biomechanics, spinal load, proprioception, movement Topics: Sensory Systems and Motor Systems Publications: orcid Website: https://www.balgrist.ch
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Prof. Dr. rer. nat. Martin Meyer Research Focus: The focus of his research is on the relationship between hearing-language-brain. In this context, his research activities touch upon basic research-oriented questions on the evolution of prosody, rhythm and syntax as well as application-oriented aspects (the relationship of age-related hearing loss, central auditory disorders and neuroanatomical plasticity as well as the neuroplasticity of tinnitus). Keywords: Evolution of language and communication, functional neuranatomy of language and hearing, neuropsychology of language across the lifespan, neuroplasticity of tinnitus, neuromodulatory approaches in the treatment of chronic tinnitus, neurocognitive aspects of hearing loss, age-related hearing loss (presbycusis) and atrophy Topic: Cognitive Neuroscience Publications: https://www.comparativelinguistics.uzh.ch/en/ENL/Publications.html Website: https://www.comparativelinguistics.uzh.ch/en/ENL.html https://www.tinnitus.uzh.ch/de.html
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Prof. Dr. Urs Meyer Research Focus: Our main research interest is centered upon the question of how early-life environmental adversities such as prenatal infection, pubertal stress, and nutritional imbalances can influence brain development and shape the risk of long-term brain abnormalities. Our work combines behavioral and cognitive tests, immunological assays and neuroanatomical techniques in rodent models, including models of gene-environment and environment-environment interactions relevant to multifactorial neurodevelopmental disorders such as schizophrenia and autism. Our research also includes molecular investigations to examine the role of epigenetic processes in environmentally induced brain pathologies and uses pharmacological approaches with the aim to establish novel symptomatic and preventive treatments against chronic brain disorders with neurodevelopmental origins.
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PD Dr. Lars Michels Research Focus: My research foci are on the understanding of basic neurophysiological processes as well as structural and functional brain connectivity and plasticity during brain development, aging, and brain disorders (dementia and migraine). To address these questions, I am using a multimodal imaging (and neurostimulation) approach, including techniques such as structural MRI, spinal cord fMRI, high-density EEG, EEG-fMRI, (dynamic) ASL, MR spectroscopy, DTI, QSM, iVASO, WEPCAST, and tDCS. Currently, I am investigating the impact of real-time fMRI neurofeedback intervention on attention and visual brain processing and (tDCS) neurostimulation for reducing migraine. Keywords: basic neurophysiology, multimodal brain imaging, aging, EEG-fMRI, neurostimulation, neurofeedback, short-term memory. Topics: Cognitive neuroscience, Disorders of the Nervous System Publications: researcherid.com PubMed Google Scholar Website: www.neuroradiologie.usz.ch (go to “Forschende”)
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Dr. Linjing Mu linjing.mu@usz.ch linjing.mu@pharma.ethz.ch Research Focus: Our group focuses on non-invasive positron emission tomography (PET) tracer development for imaging neurodegenerative diseases. We are working on several targets including the glutamate receptors, cannabinoid and endocannabinoid systems and ATP Synthase. To characterize the target, murine and post-mortem human tissues will be used to analyze the target in various diseases by qPCR, confocal microscopy and flow cytometry; in vitro autoradiography will be employed to understand the tracer’s specificity and selectivity. Depends on the target, different animal models will be used for in vivo PET imaging. In our GMP lab, several CNS PET ligands are routinely synthesized and applied for drug development and studying brain functions. Keywords: PET tracer development, non-invasive PET imaging, drug development, Alzheimer’s disease, neuroinflammation. Topic: Biomedical Technology and Imaging Publications: orcid |
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Prof. Dr. Martin Müller Research Focus: We are interested in understanding how characteristic functional properties of synapses are established, maintained, and modulated. What are the mechanisms that stabilize synapse function, and how are these mechanisms related to processes that alter synaptic activity? We study these questions using a combination of genetics, electrophysiology, and functional imaging of synaptic transmission in Drosophila. We are also in the process of translating interesting findings from Drosophila into the mammalian central nervous system. We hope that our work may help unraveling the mechanisms that are involved in preventing uncontrolled neural activity during neural pathology, while providing the nervous system with the capacity for change. Keywords: Synaptic transmission, homeostatic plasticity, synaptic plasticity, electrophysiology, Ca2+ imaging, genetics, Drosophila, mouse brain slices Topic: Molecular and Cellular Neuroscience Publications: http://www.imls.uzh.ch Website: http://www.imls.uzh.ch/mueller |
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Prof. Dr. med. Giancarlo Natalucci Research Focus: will follow Keywords: outcome, child development, neurodevelopment, quality of life; nutrition; neuroprotection, neuromonitoring, post-discharge supportive intervention; parenting; preterm birth, intrauterine growth restriction (IUGR), hypoxic-ischaemic encephalopathy; cohort study. Topic: Disorders of the Nervous System Website: http://www.neonatologie.usz.ch
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Prof. Dr. Stephan Neuhauss Research Focus: We exploit the superb genetics of the zebrafish (Danio rerio) model system to study the development and function of the vertebrate visual system and its diseases. Our current research focuses on the adaptation of the cone photoreceptor visual transduction cascade, glutamate homeostasis in the cone photoreceptor synapse and building genetic disease models for retinal dystrophies. We use a combination of molecular genetics, histology, electrophysiology and behavioral analysis. Additionally we are interested in the evolution of protein families involved in vision in chordates. Keywords: Retina, Vision, Zebrafish, Cone Photoreceptors, Synaptic Transmission, Glutamate, Evolution Topic: Sensory Systems Publications: PubMed Website: https://www.mls.uzh.ch |
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Dr. Ruiqing Ni Research Focus: My research goal is to understand the mechanisms underlying Alzheimer’s disease, with a focus on detecting aberrant brain network activity, Aβ, tau and neurodegeneration by using multiscale high-resolution neuroimaging techniques (MRI, Optoacoustic tomography, PET). |
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Prof. Dr. Roger Nitsch
Website: http://www.irem.uzh.ch
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Dr. Daniela Noain Research Focus: What restorative and/or neuroprotective processes unfold in the sleeping brain? Is slow-wave sleep a key player to their regulation and execution? And, therefore, could slow-wave sleep modulation be used to influence the course of neuropathological processes? The focus of our research is exploring the role of slow-wave sleep in the levels of brain proteins that lead to neurodegeneration. Aiming at implementing translational and highly specific slow-wave sleep modulation strategies in transgenic rodent models of disease, we develop innovative techniques, such as closed-loop acoustic stimulation of slow oscillations. Our ultimate goal is providing tools for and proof that modulations of slow-wave sleep regulate protein clearance in the sleeping brain and, therefore, could be translated into novel non-invasive human therapies against Alzheimer and Parkinson Disease, the two most common protein aggregation-related neurodegenerative diseases. Keywords: Slow-wave sleep, modulation of sleep-wake states, neurodegeneration, Alzheimer disease, Parkinson disease, traumatic brain injury, brain clearance, behavioral testing. Topic: Sleep and Sleep Disorders, Disorders of the Nervous System Publications: PubMed Google Scholar Website: http://www.sleep.uzh.ch
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Dr. Tina Notter Research Focus: The main research focus of our group is to define the role of astrocytes in postnatal synaptic refinement of the prefrontal cortex (PFC). One distinctive feature of the PFC is its protracted adolescent maturation, which is necessary for acquiring mature cognitive abilities in adulthood. One of our primary aims is to determine the role of astrocytes in the structural and functional maturation of the PFC. Long thought to act merely as a structural support of neurons, astrocytes are now known to actively integrate, process and contribute to neuronal signaling. They are essential for early brain development regulating synaptogenesis and assuring correct wiring of the brain. More recently, astrocytes have been shown to actively participate in the rewiring of neuronal connections during brain maturation, a process involving the elimination of superfluous synapses, whereby neuronal circuits are optimized. Using a multi-disciplinary approach including chemogenetics, in-vivo two-photon imaging, immunohistochemistry, and behavioral analyses in mouse models, we investigate whether astrocyte-dependent synaptic elimination is indispensable for the normal development of neuronal networks subserving adult cognitive functions. In addition, we thrive to unravel the functional and behavioral consequences of aberrant astrocyte activity in the matured PFC. We hereby focus on understanding how astrocytes actively integrate, process and contribute to PFC synaptic signaling and thereby modulate behavioral and cognitive functions with relevance to psychiatric disorders. Keywords: Astrocytes, medial prefrontal cortex, brain maturation, adolescence, synaptic refinement, cognition, behavior, psychiatric disorders Topics: Neural Basis of Behavior, Development and Regeneration, Molecular and Cellular Publications: PubMed
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Dr. Ruth O'Gorman Tuura Research Focus: Our research focuses on the application of advanced MRI methods for evaluating brain physiology, such as arterial spin labelling perfusion MRI, edited MR spectroscopy, diffusion tensor MRI, functional MRI, and quantitative MR Relaxometry, to studies of brain development in children and adolescents. This multimodal approach yields important insight into the complex pattern of physiological changes associated with typical and atypical brain development, but also with different brain states like sleep and wake states. Together with our clinical collaborators, we aim to improve our understanding of the neural correlates of atypical development, and identify neuroimaging biomarkers for outcome in infants and children at risk for neurodevelopmental impairment. We also support interdisciplinary clinical research across a range of specialties including neonatology, cardiology, radiology, paediatrics, neurology, and psychiatry Keywords: neuroimaging, structural MRI, MRS, DTI, fMRI, perfusion MRI, development, sleep Topics: Development and Regeneration” and “Sleep and Sleep Disorders” Publications: scopus Website: https://www.kispi.uzh.ch
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Prof. Dr. Tommaso Patriarchi Research Focus: The sheer complexity of neural communication relies on the production and secretion of various neurochemicals. A central question in neuroscience is to understand how precise fluctuations of these molecules relate to behavioral and/or disease states. Yet, technologies capable of addressing this question in living animals with the required spatiotemporal resolution and molecular specificity are largely lacking. Our Group focuses on developing novel genetically encoded fluorescent sensors based on combined engineering of fluorescent proteins and endogenous receptor molecules (e.g. G-protein coupled receptors) to enable specific and high-resolution optical dissection of neurochemical dynamics in living animals. We aim to combine these molecular tools with state of the art in vivo imaging techniques (fiber photometry, two-photon imaging, optoacoustics) for investigating how neurochemicals orchestrate complex behavioral functions. Keywords: genetically encoded sensors, GPCRs, fluorescent proteins, neuromodulators, neuropeptides, neuroimaging. Topics: Biomedical Technology, Molecular and Cellular Neuroscience Publications: Google Scholar |
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Prof. Dr. Melika Payvand Research Focus: The question that drives us is to understand how intelligence emerges from the structure of its underlying substrate which will result in building intelligent systems. We combine the understandings from neuroscience, machine learning, and electrical engineering in a co-design fashion towards building low-power and high-density intelligent systems. We are specifically interested in building learning systems that can self-organize to the sensory information they receive. These systems have applications in a variety of autonomous sensory-motor systems and personalizing edge devices. Topic: Computation and Modelling Publications: PubMed Website: https://services.ini.uzh.ch/people/melika
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Dr. Daria Peleg-Raibstein, Junior Group Leader Research Focus: Obesity has long been identified as a global epidemic with major health implications such as diabetes, cardiovascular disease and cancer. Maternal overnutrition and maternal obesity are significant health issues in industrial countries and are known risk factors for the development of obesity and related disorders in the offspring. The wide accessibility of junk food in recent years is one of the major causes of obesity. An excess of nutrients during fetal life not only has immediate effects on the fetus but also has long term effects on adult health. Our interest is on how maternal overnutrition can affect the development and function of the central nervous system circuits that regulate reward-related behaviors and cognitive disabilities in the offspring. We are also interested in the impact of maternal overnutrition and lifelong obesity and related metabolic consequences in the offspring. Keywords: Obesity, addiction, maternal high-fat diet, development, cognitive functions, epigenetic, dopamine, translational research Topic: Neural Basis of Behavior Publications: PubMed Website: http://www.tnb.ethz.ch
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Prof. Dr. Francesca Peri Research Focus: Most aspects of brain development, function and, repair are not mediated by neurons alone but emerge from their interactions with other cell types. Of particular interest are microglia, the brain resident macrophages that can shape neuronal connectivity by removing dying neurons and synapses. By taking an in vivo approach that combines quantitative live imaging and cutting-edge perturbations in zebrafish, we study how microglia engulf neurons at single-cell resolution. To investigate this, we have developed tools to visualize and manipulate signals that control neuronal-microglia interactions and custom-designed microscopes that allow multi-positioning in toto brain imaging at subcellular resolution. Keywords: Microglia, neuronal cell death, development, cell biology, neuroinflammation Topic: Neuroimmunology, Endocrine and Autonomic Regulation |
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Prof. Dr. Jean-Pascal Pfister Research Focus: One of the most fascinating properties of the brain is its ability to extract relevant information from the environment (e.g. extract the voice of a single person in a crowd, recognize an object when only part of it is observed). However very little is known about how this feature extraction is performed in the brain. I am particularly interested in better understanding how this feature extraction is implemented at the level of neurons and synapses. More generally, I am interested in developing new statistical models and apply them in the field of neuroscience. This statistical approach in neuroscience is mainly focused at the level of spiking neurons. Keywords: Bayesian Inference, Learning, Synaptic Plasticity, Spiking Neurons, Statistical Models Topic: Computation and Modeling Projects: https://www.ini.uzh.ch/ Publications: Google Scholar Website: https://www.ini.uzh.ch
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Prof. Dr. Paola Picotti
Topic: Disorders of the Nervous System Website: https://imsb.ethz.ch
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Prof. Dr. Rafael Polania Research Focus: Humans do not react to the environment in a reflexive manner, but can freely choose which action to perform in response to a given situation. The neural processes that enable such flexible decision making are fundamental components of human cognition and have attracted a lot of interest from researchers in many scientific disciplines such as neuroscience, psychology, economics, and medicine. The research agenda at the Decision Neuroscience Lab bridges these multiple disciplines across theoretical and empirical domains to establish important links between the computational, psychological and neural processes controlling human decision making, by providing both correlative and causal evidence that well-defined neural signals are indeed driving both computationally defined cognitive processes and the resulting behavior. This research thus has the potential to unite conceptually separate approaches to the study of distinct types of human behavior and thereby contribute information that is crucial for the diagnosis and treatment of psychiatric and neurological disorders involving decision-making pathologies (e.g. ADHD, obesity, addiction). Topics: Cognitive Neuroscience, Computation and Modeling, Neural Basis of Behavior Keywords: decision-making, EEG, fMRI, non-invasive brain stimulation, reward, perception, economics. Publications: Google Scholar
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Prof. Dr. Magdalini Polymenidou
Topic: Disorders for the Nervous System Website: https://www.dqbm.uzh.ch
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Dr. Basil Preisig Research Focus: Hearing loss and associated conditions such as tinnitus are the fourth highest cause of disability worldwide. A common complaint of hearing impaired individuals is the significant decline of speech comprehension in the presence of noise. This applies particularly to socially relevant situations, such as discussions with several interaction partners. Unfortunately, state of the art hearing aids cannot selectively amplify one out of several speakers. My team’s research aims to elucidate the role of brain activity during auditory selective attention. More specifically, we want to understand how the brain instantiates attentional filter mechanisms that control target amplification and distractor suppression. Indeed, neuronal processes of attention control maybe impaired in hearing loss and tinnitus. However, it is still unclear whether different subprocesses like target enhancement and distractor suppression are affected differently. We aim to identify neural makers of these subprocesses in individuals with hearing loss and tinnitus using electroencephalography. Subsequently, we will test the relevance of the identified markers using cutting-edge non-invasive electric brain stimulation and neurofeedback interventions. Our findings might provide important foundations for the development of future therapeutic brain stimulation and neurofeedback interventions. In addition, the results may stimulate the technical advances relevant for the implementation of attention control in next generation hearing aids. Keywords: auditory, attention, speech perception, language comprehension, EEG, non-invasive brain stimulation, neurofeedback, hearing loss, tinnitus Topic: Cognitive Neuroscience, Sensory Systems Publications: Google Scholar Website: https://www.comparativelinguistics.uzh.ch
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Prof. Dr. Klaas Prüssmann
Topic: Biomedical Technology and Imaging Website: https://ee.ethz.ch
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Prof. Dr. Christopher Pryce Research Focus:Mouse models aimed at identifying the causal pathways via which chronic psychosocial stress can lead to excessive fear and deficient motivation. Stress-immune-glia-neuron dysfunction is a pathway of major interest, and amygdala a structure of major interest. Keywords: Stress, immune-inflammation, amygdala, oligodendrocyte, neuron, fear, motivation Topics: Neural Basis of Behavior, Disorders of the Nervous System Publications: PubMed Website: https://www.med.uzh.ch |
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Prof. Dr. rer. nat. Boris B. Quednow Research Focus: Pharmacopsychology – today a subdiscipline of neuropsychology and biological psychology – was founded by the famous German psychiatrist Emil Kraepelin (1856-1926) and aims to explore the neurochemical basis of human cognition, emotion, and behavior. Standing in Kraepelins tradition, our main research goal is a better understanding of the neuropsychopharmacological mechanisms of cognitive and emotional brain functions and their impact specifically on social behavior in humans. We are currently investigating the neuroplasticity and behavioral neurotoxicity induced by chronic use of legal and illegal drugs, such as nicotine, methylphenidate, cocaine, MDMA (“ecstasy”), GHB, opioids, and cannabis. Furthermore, we study the molecular and neuronal basis of impaired early information processing (e.g., pre-attentional gating) up to complex cognitive functions (e.g., empathy) in psychiatric diseases such as addiction, schizophrenia, and depression. Keywords: Neuroenhancement, drug dependence, psychosis, affective disorders, endophenotype, genetics, sensorimotor gating, prepulse inhibition, neuropsychology, social cognition, decision-making, neuroeconomics, molecular imaging, PET Topic: Cognitive Neuroscience Publications: PubMed Website: https://www.dppp.uzh.ch |
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Prof. Dr. med. Georgia Ramantani Research Focus: We aim to improve diagnostic tools for focal epilepsy, particularly in the context of epilepsy surgery, and establish pertinent biomarkers for postsurgical seizure outcomes deriving from electrophysiology and neuroimaging studies. Furthermore, we strive to provide deeper insights into the cognitive development after epilepsy surgery and to facilitate the selection of appropriate candidates. Finally, we aspire to study the processes of epileptogenesis in the immature brain, particularly in the context of neonatal seizures, and develop prognostic tools for outcome prediction. Keywords: pediatric epilepsy; epilepsy surgery; biomarkers; outcome prediction; cognitive development; epileptogenesis; neonatal seizures Topic: Disorders of the Nervous System Publications: PubMed Website: https://www.kispi.uzh.ch/forschungszentrum/forschungsgebiete/eeg-forschung
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Prof. Dr. Nora Maria Raschle Research Focus: In our laboratory we study typical and atypical brain development with a particular focus on socioemotional and cognitive processes. In order to assess such trajectories we employ magnetic resonance imaging techniques (f/MRI), eye-tracking, neurophysiological assessments, behavioral testing and clinical interviews. Our main goal is to contribute towards the early detection and characterization of developmental and mental health disorders. And most importantly, we always strive towards making paediatric neuroimaging child’s play, a fun and beneficial experience for all. Our main areas of interest include: paediatric neuroimaging, brain development, brain structure, function and connectivity, socioemotional skills (emotion processing and emotion regulation), language and reading, learning, plasticity and resilience Keywords: fMRI, MRI, brain development, paediatric neuroimagng, emotion, emotion regulation, conduct disorder, reading, developmental dyslexia Topic: Cognitive Neuroscience, Disorders of the Nervous System Website: https://www.jacobscenter.uzh.ch |
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Prof. Dr. Anita Rauch
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PD Dr. med. Katrin Rauen, Junior Group Leader Research Focus: The overarching goal is to identify and validate clinical, blood, and advanced neuroimaging markers for patients suffering from acute or chronic TBI over the lifespan, thereby providing new clinical diagnostic algorithms and knowledge on the link between chronic neuroinflammation and posttraumatic neurodegeneration. This approach will help to develop new pharmacological and neuropsychiatric rehabilitation strategies for TBI patients, and thus will provide best quality of life for TBI patients and their relatives. Keywords: Traumatic brain injury, neuropsychiatric burden, clinical trials, clinical diagnostic algorithm, chronic neuroinflammation, posttraumatic neurodegeneration, neuropsychiatric rehabilitation, neurotrauma outcome and quality of life. Topics: Disorders of the Nervous System, Neuroimmunology Publications: PubMed Google Scholar Social Media: linkedin and twitter Websites: www.pukzh.ch and https://europeanneutrotrauma.org and www.sleep.uzh.ch
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Prof. Dr. Daniel Razansky Research Focus: Neuroscience has an urgent need for new large-scale neural recording technologies to ensure rapid progress in the understanding of brain function, diagnosis and treatment of neurological disorders. At present, real-time visualization of large-scale neural dynamics is hindered with the existing neuroimaging methods due to lack of capacity for direct imaging of neural activity in large tissue volumes and at high speeds. We develop novel functional neuroimaging tools based on optoacoustics, optical microscopy, ultrasound and magnetic resonance imaging to volumetrically monitor activity of large distributed neuronal populations in whole mammalian brains with unprecedented spatial and temporal resolution. Keywords: molecular imaging, functional neuroimaging, optoacoustics, microscopy, ultrasound, fMRI Topics: Biomedical Technology and Imaging Publications: Google Scholar Website: http://www.razanskylab.org
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Prof. Dr. med. Luca Regli
Website: https://usz-international.com |
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Dr. Juliet Richetto Research Focus: Main research interests are centered upon the question of how early-life environmental adversities, such as prenatal infection or prenatal maternal isolation, can influence brain development and shape the risk of long-term brain abnormalities. Currently, we are investigating whether maternal social isolation, and concomitant pharmacological interventions, lead to genome-wide alterations in DNA methylation and gene expression in the offspring’s brain, which in turn may impact pathways and neuronal systems that underlie behavioral functioning. In addition, we are starting to explore how the microbiome may affect CNS functioning through epigenetic mechanisms. Our research is performed in mice models and combines behavioral neuroscience, neuroanatomical investigations, transcriptomics and epigenomics. Keywords: Epigenetics, social isolation, prenatal infection, prenatal stress, depression, transcriptomics, microbiome Topics: Disorders of the nervous system, Neural basis of behavior, Molecular and cellular neuroscience.
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Prof. Dr. Ing. Robert Riener Research Focus: Robert Riener and the members of his Sensory-Motor Systems (SMS) Lab investigate the sensory-motor actions in and interactions between humans and machines. The research focuses on the study of human sensory-motor control, the design of novel mechatronic machines, and the investigation and optimisation of human-machine interaction. Riener’s Lab has developed famous rehabilitation robots (such as the ARMin) and virtual reality technologies applied to the area of neurorehabilitation. Main application areas are the fields of neuro-rehabilitation and sports. R. Riener is also the initiator and organiser of the Cybathlon 2016 in Kloten, Zurich. Keywords: Neurorehabilitation, rehabilitaiton robotics, motor learning, control of motion, biomechatronics
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PD Dr. Marta Roccio Research Focus: Specialized sensory cells located into the inner ear translate with remarkable speed and accuracy sound-induced vibrations of different loudness and pitch into chemical signals that can be interpreted by the brain as sound. Loss or damage of these sensory cells results in permanent hearing loss as the human inner ear cannot repair after damage. The long-term goal of our research is to develop novel therapeutic strategies to counteract sensorineural hearing loss by uncovering fundamental biological principles that underlay development and disease. We are making use of in vitro models known as “inner ear organoids”, derived from directed differentiation of pluripotent stem cells (PSCs) to gain insight into inner ear sensory organ development and use them as unique tools to model disease. In addition we exploit cochlear organoids culture from inner ear progenitors to probe tissue regenerative potential. By leveraging recent advances in bioengineering, organoid culture and organ-on-chip technology, we aim to develop reproducible and robust in vitro models to study inner ear development, model disease and analyze drug-induced ototoxicity and otoregeneration. Methods: PSC derived inner ear organoid, cochlear progenitor culture, in vitro screening Keywords: Inner ear development, Hearing loss, Neuroscience, Disease Modeling Topics: Development and Regeneration, Sensory Systems Publications: scopus Website: http://www.orl.usz.ch
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PD Dr. med. Christof Röösli Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich Research Focus: Bone conduction hearing is an alternative pathways for sound to reach the inner ear. In includes vibration of the tissue that is transmitted by several pathays to the cochlea. Our focus is to investigate these transmission pathays using an experimental approach, using computational models, and physical models. The goal is to gain a profound understanding of bone conduction hearing to lay the basis for the development of novel hearing aids. We are an interdisciplinary research team of graduates from different specialties, with competence in investigation techniques of acoustics, vibro-mechanics and electrophysiology. Keywords: Hearing, Bone conduction, Implants Topics: Sensory Systems Website: https://www.usz.ch
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PD Dr. med. Patrick Roth Keywords: Brain cancer, glioblastoma, immune escape, immunotherapy Topic: Disorders of the Nervous Systems Publications: PubMed Website: https://www.usz.ch
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Prof. Dr. Michael Rufer Research Focus: One important focus is the emotion regulation and dysregulation in psychosomatic and psychiatric disorders. This includes the evaluation of different psychological constructs, such as alexithymia and dissociation, the development of assessment methods, and the investigation of neural correlates of emotion regulation. Further main research areas are multidisciplinary approaches on different aspects of the relationships between psychology and medicine, psychotherapeutic processes and outcomes, including neurobiological aspects, and technology-based psychological interventions (Internet-based and mobile interventions) for different disorders, such as anxiety and obsessive compulsive spectrum disorders. Keywords: Emotion regulation, alexithymia, dissociation, psychotherapy, psychosomatics, neurobiology, internet-based therapy Topics: Cognitive Neuroscience, Disorders of the Nervous System, Neural Basis of Behavior Publications: PubMed Website: https://www.pukzh.ch
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Prof. Dr. Christian Ruff Keywords: Decision-making, goal-directed behavior, social behavior, perception, reward processing, non-invasive brain stimulation Website: https://www.econ.uzh.ch
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Dr. Ruslan Rust, Junior Group Leader Keywords: Cell therapy, iPSCs, NPCs, stroke, brain injury, CNS, regeneration, preclinical animal models, in vivo imaging, big data analysis, deep learning Topic: Disorders of the Nervous System, Molecular and Cellular Neuroscience Publications: Google Scholar Website: https://www.irem.uzh.ch |
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Prof. Dr. Aiman Saab |
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Prof. Dr. Johannes Sarnthein Research Focus: Establish neurophysiological biomarkers to improve the outcome of neurosurgical interventions. We correlate intraoperative measurements with postoperative outcome to optimize the neurophysiological guidance of the surgeon. We analyze data obtained during surgery to investigate the physiological mechanisms involved. For example, high-frequency oscillations (HFO) are a promising new marker for epileptogenic brain tissue in intracranial recordings in epilepsy patients, both before and after resection of the epileptogenic zone. Keywords: intraoperative neuromonitoring; patient registry; tumor; epilepsy Topic: Biomedical Technology and Imaging Publications: PubMed Google Scholar Website: https://hfozuri.ch
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Dr. Marianne Schmid Daners Research Focus: At the interdisciplinary interface of clinical research and engineering my research focuses on the modelling, control and testing of biomedical systems as well as on the development and control of devices for the treatment of hydrocephalus. One particular focus is to gain fundamental insights into the physiologic dynamics within and adjacent to the cerebrospinal fluid spaces and to develop a pathologic hydrocephalus model. In addition, my research on the cardiovascular system contributes to the understanding of intracranial and spinal dynamics and may support further work on brain perfusion. Keywords: pressure interaction, testing, sensors, physiologic control, gait analysis, hydrocephalus Topic: Computation and Modeling, Biomedical Technology and Imaging, Disorders of the Nervous System Publications: publons Website: https://pdz.ethz.ch
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Dr. Edith M. Schneider Gasser, Junior Group Leader Research Focus: We are investigating the involvement of cerebral erythropoietin (Epo) in brain maturation and its neuroprotective role in premature brain injury. Our current research focuses on understanding how Epo influences brain energy metabolism and the interactions between blood vessels, astrocytes and neurons. We are also investigating the protective role of Epo in models of hypoxia induced brain injury and epilepsy. Keywords: Erythropoietin, hypoxia, epilepsy, neuroprotection, hippocampus, interneurons, brain metabolism Topic: Development and Regeneration, Disorders of the Nervous System Publications: PubMed Websites:http://www.pharma.uzh.ch
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Prof. Dr. Gerhard Schratt Research Focus: The correct formation and use-dependent modification of neuronal networks in the brain is a prerequisite for higher cognitive functions and complex behaviours. Disturbances in these processes can lead to severe neurodevelopmental and psychiatric disorders, such as autism and affective disorders. Research over the last three decades has identified activity-dependent gene expression programs that control the formation and plasticity of neuronal synapses. However, these studies mostly focussed on the role of protein-coding genes, which are encoded in less than two percent of our genomic material. In our lab, we want to understand the function of different classes of RNAs that originate from non-coding parts of the genome (so-called non-coding RNAs) in mammalian synapse development and plasticity. A major focus is on microRNAs, small regulatory RNAs that control the expression of protein-coding genes at the post-transcriptional level. Therefore, we employ a systems approach, combining state-of-the art genomics, proteomics and mouse genetic approaches. In addition, we are addressing a potential clinical relevance of non-coding RNA pathways in different neurological conditions through multicentre collaborations. Keywords: excitatory synapse development, synaptic plasticity, homeostatic plasticity, non-coding RNA, microRNA, knockout mice, hippocampus, social behaviour, epilepsy Topic: Molecular and Cellular Neuroscience Publications: PubMed Website: https://www.neuroscience.uzh.ch
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Prof. Dr. Martin E. Schwab The laboratory also analyses the functional roles of Nogo-A as a stabilizer of the CNS circuitry and of synapses, including processes of memory formation. On the cell biological level, we analyse the multi-subunit composition of Nogo-A receptors and their relation to the specific effects of Nogo-A on the neuronal cytoskeleton and gene transcription. Keywords: Nogo-A, nerve fiber growth, regeneration, plasticity, spinal cord and brain injury, myelin, neurite growth inhibitory activity, rehabilitation Topics: Disorders of the Nervous System, Development and Regeneration, Molecular and Cellular Neuroscience Publications: PubMed Website: https://hest.ethz.ch/
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PD Dr. med. Petra Schweinhardt Research Focus: Albeit nociception and pain are closely linked, there is no 1:1 relationship because the central nervous system hugely modulates nociceptive processing in a facilitatory as well as an inhibitory way. Our research focuses on how the CNS, in particular the brain, modulates nociception and how an altered balance between facilitation and inhibition contributes to chronic pain in patients. We use brain imaging methods (magnetic resonance imaging and spectroscopy) and psychophysical techniques to understand cerebral processes resulting in augmented nociceptive processing. We specifically investigate how contextual threat cues lead to sensitization along the neuraxis, thereby contributing to chronic pain. Keywords: pain modulation, threat, MRI, MRS Topics: Sensory Systems, Disorders of the Nervous System Publications: PubMed Webpage: https://www.balgrist.ch
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Dr. Maryam Seif, Junior Group Leader Research Focus: Our vision is to develop and apply neuroimaging biomarkers in human CNS following spinal cord injury (SCI) to better understand the SCI-induced neurodegeneration and predict the functional outcome. We use novel quantitative magnetic resonance imaging (qMRI) in the brain and spinal cord. qMRI is expected to provide sensitive biomarkers of (micro-) structural changes of CNS due to trauma or neurodegeneration. Neuroimaging biomarkers hold promises to improve clinical trial design and efficiency through better SCI patient stratification. Keywords: quantitative MRI, neuroimaging biomarker, spinal cord injury Topic: Biomedical Technology and Disorders of the Nervous System Webpage: https://www.sci-research.uzh.ch
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Prof. Dr. Erich Seifritz
Publications: PubMed Website: http://www.dcp.uzh.ch
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PD Dr. Jae Hoon Sim Research Focus: We have performed both basic science and clinical researches on middle-ear mechanics and middle-ear surgeries. The researches on the middle mechanics have been focused on anatomical characteristics of middle ears in mammals, sound transmission through the middle ear, protective and adaptive functions of the human middle ear whereas the researches on middle-ear surgeries explore stability and reliability of middle-ear implants, assessment of expected surgical outcomes, optimization of prostheses and surgical conditions for the best performance, and surgical flexibility under anatomical variation across subjects. Our team has established and used novel and unique techniques to perform the researches. The methodological approaches include 1) measurements of quasi-static and vibrational motions of the middle-ear ossicular chain and protheses in 3D space, 2) micro-imaging of the middle-ear structures, and 3) development of comprehensive biomechanical models of the intact and surgically-reconstructed middle ears. Keywords: middle-ear mechanics, middle-ear reconstruction Topic: Sensory Systems, Biomedical Technology and Imaging Publications: PubMed
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Prof. Dr. Lukas Sommer Research Focus: Using genetic approaches in mouse model systems combined with cell biological assays, we are investigating how self-renewal and lineage-specific differentiation are controlled in vertebrate stem cells. Our favourite research topic are neural crest stem cells, which have a very broad developmental potential and give rise to multiple tissues in our body, including most of the peripheral nervous system, craniofacial bone and cartilage, smooth muscle in the outflow tract of the heart, and melanocytes in the skin. Our research aims to identify mechanisms underlying neural crest stem cell development associated with congenital diseases, tissue regeneration, and tumor formation. Keywords: stem cells, embryonic development, developmental disorders, cancer Topic: Development; Molecular and Cellular Neuroscience Publications: PubMed Website: https://www.anatomy.uzh.ch
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Prof. Dr. Hans H. Stassen Research Focus: Today, the question of predicting treatment response in the individual patient is not answerable for any of the currently available antipsychotics and antidepressants. In tandem with the benefits of these medications are significant risks associated with their use. This is particularly true for polypharmacy approaches where patients receive combinations of various drugs. Our research focus lies on “objective” prediction methods for the individual patient that avoid (1) unnecessarily long treatments with ineffective drugs; and (2) acute side effects that are quite uncomfortable for patients and compromise compliance with otherwise beneficial treatments. Another focus lies on the early detection of insufficient coping behavior under chronic stress which may raise blood pressure, increase the risk of heart attack and stroke, suppress the immune system, and increase the vulnerability to psychiatric disorders, such as anxiety, depression, or schizophrenia. Keywords: Antidepressants, antipsychotics, polypharmacy, unwanted side effects, inflammatory response system, prediction of treatment response, early detection and prevention, stress, coping behavior Topic: Disorders of the Nervous System Publications: PubMed
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Prof. Dr. Angelika Steger Publications: pubmed Website: https://inf.ethz.ch/people/person-detail.steger.html
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Prof. Dr. Dr. med. Robert Steinfeld robert.steinfeld@kispi.uzh.ch Keywords: neurometabolic diseases, neurodegenerative disorders, blood-CSF-barrier, nanoparticles Topic: Disorders of the Nervous System, Molecular and Cellular Neuroscience Publications: pubmed
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Prof. Dr. Klaas E. Stephan
Topic: Computation and Modeling Website: http://www.translationalneuromodeling.org
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Prof. Dr. Esther Stoeckli Research Focus: Correct wiring of the nervous system is key to its function. Many neurodevelopmental disorders, such as intellectual disability or autism, are a consequence of aberrant formation of neural networks. Our research focuses on the characterization of molecular mechanisms underlying the formation of neural circuits in health and disease using mouse and chicken embryos as model organisms. We use mainly in vivo approaches to understand the regulation of axonal behavior at intermediate targets or along their trajectories to final targets. Keywords: axon guidance, choice points, disease genes, spinal cord Topics: Development and Regeneration, Molecular and Cellular Neuroscience, Disorders of the Nervous System Publications: PubMed Website: https://www.mls.uzh.ch
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Prof. Dr. Dominik Straumann
Topic: Sensory Systems Websites: www.neurologie.usz.ch
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Prof. Dr. Ueli Suter Research Focus: Neuron-Glia Interactions & Myelination in Development, Plasticity & Disease Keywords: Myelin, plasticity, regeneration, repair, neuropathy, multiple sclerosis Topic: Molecular and Cellular Neuroscience Website: http://www.mhs.biol.ethz.ch |
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Dr. Christian Tackenberg Institute for Regenerative Medicine (IREM), University of Zürich Research Focus: Our research aims to elucidate the potential of stem cells, especially induced pluripotent stem cells (iPSCs), for the use in regenerative medicine and for modeling human diseases. iPSCs are generated by reprogramming somatic cells to an embryonic stem cell-like state via ectopic expression of a distinct transcription factor cocktail. Due to their pluripotent nature, iPSCs can be differentiated into many cell types. The use of iPSCs offers the possibility for personalized regenerative therapies with autologous or allogenic cells or tissue as well as in vitro disease modeling in human cells. Currently, we are modeling sporadic Alzheimer’s disease (SAD), which is the most common age-related dementia. Using either SAD patient-derived iPSCs or isogenic cells that differ only in their SAD risk genes, we analyze disease-relevant pathomechanisms in differentiated cortical neurons and astrocytes. Keywords: Alzheimer’s disease, induced pluripotent stem cells (iPSCs), Aβ, tau, neurodegeneration, neurons, astrocytes Topics: Disorders of the Nervous System Publications: PubMed Website: https://www.irem.uzh.ch |
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Prof. Dr. Beat Thöny Research Focus: We are interested in the understanding on patho-mechanisms of (mainly) monogenetic disorders of biogenic amines, tetrahydrobiopterin (BH4) metabolism and BH4-dependent enzyme deficiencies such as tyrosine hydroxylase (TH; infantile parkinsonism) and phenylalanine hydroxylase (PAH; phenylketonuria). We combine laboratory investigations (CSF, blood, urine and DNA) and transgenic animal (mouse) models – the latter are also exploited as platforms for the evaluation of novel therapeutics, including gene therapy and pharmacological chaperons. Our current research focus is on a novel knock-in model for TH deficiency with specific loss of brain catecholamines and motor dysfunction, and on gene therapy to correct phenylketonuria, a neurometabolic disease. Keywords: Monoamine neurotransmitter deficiency, infantile parkinsonism, tyrosine hydroxylase, hyperphenylalaninemia, phenylketonuria (PKU), gene therapy Topic: Disorders of the Nervous System Publications: PubMed Google Scholar Website: https://www.kispi.uzh.ch
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Prof. Dr. Philippe Tobler Keywords: Neuroeconomics, reward, punishment, salience, risk Topic: Cognitive Neuroscience, Neural Basis of Behavior Publications: PubMed Website: http://www.econ.uzh.ch
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Prof. Dr. Shiva Tyagarajan Research Focus: Inhibitory GABAergic neurotransmission regulates neural excitability and network synchronization. Disruption in GABAergic inhibition is implicated in neuropsychiatric, neurodevelopmental and neurodegenerative disorders. The group employs diverse experimental approaches (cell biology, molecular biology, proteomics, RNA seq, morphology, confocal microscopy, protein biochemistry) to study plasticity mechanisms regulating GABAergic neurotransmission. Our research has demonstrated that activity-dependent adaptations at inhibitory postsynapse are orchestrated via the convergence of intracellular signal cascades on to the scaffolding protein gephyrin. In this process, we have developed molecular tools to specifically modulate synaptic GABAergic neurotransmission. Hence, using a combination of in vitro primary neuron culture; and in vivo animal models we study how signaling pathways regulate inhibition to alter neural excitability in both physiology and pathology. Keywords: gephyrin, dendritic protein synthesis, barrel cortex plasticity Topic: Development and Regeneration, Molecular and Cellular neuroscience, Disorders of the Nervous System Publications: PubMed Website: http://www.pharma.uzh.ch |
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Dr. Olivier Urwyler Research focus: Formation of specific synaptic connections during central nervous system (CNS) development, and remodeling of existing neuronal circuits during adulthood (synaptic plasticity), underlie essential CNS functions such as cognition, learning, and memory. Synapse formation, plasticity and stability must be precisely controlled and balanced, and their de-regulation is associated with neurodevelopmental, psychiatric and neurodegenerative disorders. Nevertheless, the mechanisms that orchestrate these processes in the CNS remain largely unknown. We combine single-cell labeling with genetic manipulation in the Drosophila CNS to investigate the molecular and cellular control of synapse formation and plasticity. On the one hand, we are particularly interested in how local regulation of the actin cytoskeleton contributes to spatial specificity of synapse formation and synaptic partner choice during development. On the other hand, we aim at understanding the roles of evoked and spontaneous neurotransmission in formation and plasticity of central synapses, and maintenance of synaptic connectivity during ageing. Keywords: Synapse formation, synaptic plasticity, CNS, Drosophila Topic: Molecular and Cellular Neuroscience, Development and Regeneration
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Prof. Dr. Huub van Hedel hubertus.vanhedel@kispi.uzh.ch Research Focus: The neurorehabilitative treatment of upper and lower extremity functions and activities in children and youths with neurological disorders presents a high challenge as the developmental status interferes with neurological, functional, cognitive, and motivational aspects. As evidence-based guidelines for assessment and treatment are scarce, our main aim is to improve the rehabilitation process of children and youths. We have three main directions for research: (i) Develop, refine, and psychometrically evaluate (clinical) assessments, including technology-based ones. (ii) Develop and assess rehabilitative interventions, with an emphasis on rehabilitation technologies and exergames. (iii) Understand how the brain reorganizes during neurorehabilitation (e.g. with EEG, fNIRS or MRI). Keywords: pediatric, rehabilitation technology, psychometric studies, effectiveness, brain reorganisation Topic: Disorders of the Nervous Systems, Motor Systems Publications: PubMed Website: http://www.kispi.uzh.ch
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Prof. Dr. med. Franz X. Vollenweider Research Focus: Our goal is to identify brain mechanisms underlying the sense of self, visual perception, social cognition and emotional processes in normal waking states and the dysfunctions of these processes in psychiatric disorders. Multiple approaches including measures of experimental psychology, information processing (e.g. PPI, p50, MMN), and brain imaging techniques (e.g. PET, fMRI, MRS) are used to identify neurocognitive markers of these functions, and to unravel predictors for novel treatment approaches. In addition, translational drug models of psychopathology (e.g. ketamine, psilocybin) are used to further elucidate the role of the glutamate and serotonin systems in psychotic symptom formation, cognition, and emotion regulation. To bridge the gap between preclinical and clinical research, we also aim further at developing new translational models to investigate clinically relevant drug effects in healthy human subjects rather than patients. Keywords: Psychopathology, Cognitive Neuroscience, Psychopharmacology, Models of psychoses, Emotion processing, glutamate, serotonin, PPI, p50, MMN, EEG-ERP, PET, fMRI, MRS Topic: Sensory Systems, Cognitive Neuroscience Publications: PubMed Website: https://www.dppp.uzh.ch
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Dr. Wolfger von der Behrens Research Focus: The central question of our research is how the nervous system adapts dynamically to the sensory environment and input on the basis of stimulus features, probability and regularity and vice-versa how this adaptation shapes perception. The model for answering these questions is the rodent primary sensory cortex with a particular focus on the neuronal representation of deviating stimuli. Deviating stimuli are of interest as they usually have a high saliency and therefore are potent trigger for reallocating the attentional focus. Neuronal activity signalling deviant stimuli is well described in human EEG recordings. Such a mismatch negativity wave in the EEG (‘MMN’) is a robust and most-likely hard-wired phenomenon. However, the underlying neuronal circuitry is unknown. In order to dissemble this circuitry we employ different behavioural and in-vivo physiological methods such as high-density single-neuron recordings and optogenetics. Additionally, these deviant-detecting circuits are disturbed in a range of neurological and neuropsychiatric disorders such as schizophrenia. Therefore, we are interested in modelling these pathologies as well due to their close and intricate relationship with the deviance detection mechanisms. Keywords: Sensory decision making, deviance detection & predictive coding, rodents, optogenetics, multi-channel electrophysiology, behaviour, auditory and somatosensory system Publications: Google Scholar |
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Prof. Dr. Janos Vörös
Topic: Biomedical Technology and Imaging Website: http://www.lbb.ethz.ch |
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Dr. Dr. Anna-Sophia Wahl Topics: Development and Regeneration, Disorders of the Nervous System Publications: Google Scholar Website: https://www.hifo.uzh.ch
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Prof. Dr. Susanne Walitza, KJPD
Topic: Disorders of the Nervous System Website: http://www.kjpd.uzh.ch |
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Dr. Thomas Wälchli, Junior Group Leader thomas.waelchli@usz.ch Research Focus: We aim to understand the cellular and molecular mechanisms that govern angiogenesis and the neurovascular unit/perivascular niche in the central nervous system (CNS), during development as well as in CNS pathologies such as brain tumors and vascular malformations. Topics: Molecular and Cellular Neuroscience, Development and Regeneration, Disorders of the Nervous System Websites: https://www.usz.chhttp://www.irem.uzh.ch |
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Prof. Dr. Bruno Weber Research Focus: Our group uses a wide range of imaging tools to study the cell-to-cell communication pathways involved in energy metabolism and information processing in cerebral cortex. Furthermore, we are working on dissecting the interaction of neurons and astrocytes with the vascular system, which is responsible for maintaining adequate delivery of oxygen and energy substrates to the brain. As well as studying these systems, the development of imaging systems for in vivo research is an additional research focus of the group. Keywords: Brain energy metabolism, glia, astrocyte-neuron-interaction, lactate Topics: Biomedical Technology and Imaging, Molecular and Cellular Neuroscience Publications: http://www.pharma.uzh.ch Website: http://www.pharma.uzh.ch
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PD Dr. Konrad Weber Topic: Sensory Systems Website: http://www.vertigocenter.ch
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Dr. Ulrike Weber-Stadlbauer Institute for Veterinary Pharmacology and Toxicology, University of Zurich Research Focus: My research focuses upon the question of how early-life environmental adversities, such as prenatal infection or nutritional imbalances, can shape the risk for neurodevelopmental abnormalities. One of my current research lines explores non-genetic transgenerational inheritance of neuronal and behavioral abnormalities relevant to major neuropsychiatric disorders, including schizophrenia and autism. More specifically, I investigate these processes in a translational mouse model of maternal gestational infection, which is an established environmental risk factor of schizophrenia and autism, thereby focusing on epigenetic alterations as candidate mechanisms. My research combines behavioral and cognitive tests, immunological assays, neuroanatomical techniques, transcriptomics and epigenomics. With our research we want to provide starting points for translational initiatives aiming at preventing the possible transmission of neuropsychiatric disease risk across generations. Keywords: Prenatal Infection, Transgenerational Inheritance, Epigenetics, Neurodevelopment, Behavior, Cognition, Schizophrenia, Autism Topic: Disorders of the Nervous System Publications:publons
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Prof. Dr. Susanne Wegener Research Focus: Thrombolysis is an effective treatment in acute ischemic stroke. However, the benefit of therapy has to be weighed against the risks, particularly intracerebral hemorrhage. Reasons for a different outcome in stroke may be an individual vulnerability/resistance to ischemia or vascular factors (type of occlusion/collaterals). Using rodent stroke models (MCAO/thrombin injection) and multimodal imaging we are studying mechanisms underlying ischemia tolerance and vascular adaptations to ischemia. Furthermore, we are interested in anatomical and functional correlates of cognitive impairment after MCA-territory stroke (sensorimotor and cognitive testing and Manganese-enhanced MRI). In a clinical project based on the analysis of patient imaging data, we plan to characterize novel imaging based predictors of therapeutic success in stroke Our goal is a continuing transfer of knowledge between clinical and experimental stroke research. Keywords: ischemic stroke, Magnetic Resonance Imaging, Middle cerebral artery occlusion, preconditioning, post-stroke cognitive impairment, cerebral blood flow Topic: Disorders of the Nervous System Publications: PubMed Websites: http://www.neurologie.usz.ch
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Dr. med. Dr. sc. nat. Tobias Weiss Research Focus: Malignant brain tumors are devastating diseases with a poor prognosis and an urgent need for better therapies. We are developing novel therapeutic approaches against primary brain tumors and brain metastasis, with a focus on novel cancer immunotherapies. For this, we use state-of-the-art disease models including cell lines, orthotopic fully immunocompetent mouse models and patient samples. In collaboration with groups at the University of Zurich and ETH Zurich, we apply cutting-edge methods in genomics, proteomics and imaging to gain a deep mechanistical understanding of these diseases. The goal of our research is the translational of novel treatment strategies to patients. Keywords: Brain Tumors, Immunotherapy, drug-development, multi-omics Topic: Disorders of the Nervous System, Neuroimmunology Publications: PubMed Google Scholar Website: https://www.usz.ch
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Prof. Dr. med. Michael Weller Research Focus: Despite multimodal treatment of surgery, radiotherapy and chemotherapy, the prognosis for patients with malignant brain tumors, notably glioblastoma, remains poor. To design novel treatment approaches, we study the microenvironment of brain tumors and explore how invasiveness and angiogenesis in brain tumors are regulated by the hosts`s brain. Further, our immunotherapy projects aim at defining the basis for a novel approaches targeting glioma-initiating cells with stem cell properties, commonly named glioma stem cells. These glioma stem cells are isolated from surgically removed tumor material and characterized for possible immunogenic properties with a focus on cell surface markers for immune recognition, with the hope to develop novel approaches of tumor stem cell-specific vaccination against brain tumors. Keywords: Glioblastoma, brain tumor, stem cells, immunology Topic: Disorders of the Nervous System Publications: PubMed Website: http://www.neurologie.usz.ch
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Prof. Dr. Nicole Wenderoth Keywords: Sensorimotor Control, Memory, Effort, Theory-of-Mind, Stroke, Cerebral Palsy, Autism, non-invasive brain stimulation, medical imaging Topic: Motor Systems Publications: PubMed Website: http://www.ncm.hest.ethz.ch
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Dr. sc. nat. Esther Werth Keywords: sleep-wake disorder, vigilance, EEG, endogenous melatonin, core body temperature, rest-activity pattern Topic: Sleep and Sleep Disorders, Disorders of the Nervous System Publications: PubMed Website: http://www.neurologie.usz.ch |
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Dr. Hans-Georg Wirsching Keywords: glioblastoma, pre-clinical drug development, immunotherapy Topic: Disorders of the Nervous System Publications: PubMed Website: www.neurologie.usz.ch |
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Prof. Dr. Martin Wolf Keywords: Near-infrared spectrophotometry (NIRS), Near-infrared imaging (NIRI), cerebral oxygenation Topic: Biomedical Technology and Imaging Publications: http://www.bmpn.ch
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Prof. Dr. David P. Wolfer Research focus: We investigate the neural basis of cognitive function in the normal and diseased brain using mouse models. Behavioral studies are combined with histological visualization and quantification of neuronal activity, stereotactic lesions, neuropharmacology, and targeted mutations. We also study the influence of normal genetic variation, environment and life style on cognitive function and the underlying brain circuitry. We are developing new approaches to assess cognitive functions of mice more efficiently and reliably in a fully automated social home cage setting (IntelliCage). Keywords: behavioral neuroscience, cognitive neuroscience, high throughput behavioral phenotyping Topic: Neural Basis of behavior, Cognitive Neuroscience Publications: http://www.dpwolfer.ch
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Prof. Dr. Bernd Wollscheid Keywords: Chemical & Systems Biology, Cellular Signaling, BioMedical Proteomics Topic: Biomedical Technology and Imaging Publications: Google Scholar Website: https://hest.ethz.ch
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Prof. Dr. Mehmet Fatih Yanik Topic: Biomedical Technology Website: https://ee.ethz.ch/ |
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Prof. Dr. Hanns Ulrich Zeilhofer Research Focus: The spinal dorsal horn serves a pivotal role as the first site of cellular and synaptic integration of somatosensory information. It plays a key role in diseases such as chronic pain and itch. Our group focuses on the organization and function of dorsal horn neuronal circuits and their plasticity in different pathologies. We use a variety of neuronal tracing techniques to analyse the integration of dorsal horn neurons into neuronal circuits in mice and combine virus-based and genetic tools to manipulate specific subpopulations of dorsal horn neurons in vivo. Behavioral test and in vivo 2-photon imaging and electrophysiology are used to study the function of neurons and circuits under physiological conditions and in chronic pain and itch states. Keywords: Spinal cord, interneurons, circuits, pain Topics: Molecular and Cellular Neuroscience, Disorders of the Nervous Systems, Neural Basis of Behavior, Sensory Systems Publications: PubMed Website: http://www.pharma.uzh.ch
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Prof. Dr. Xiaomin Zhang Research Focus: Episodic memory enables us to remember daily life events that occurred at particular times and places. However, newly encoded episodic memories are typically fragile due to constant interference with ongoing experiences and therefore require consolidation to form long-lasting memories. Our goal is to understand the cellular and circuitry mechanisms underlying episodic memory consolidation in healthy and Alzheimer’s disease animal models. Taking advantage of in vivo electrophysiological recordings and advanced optical tools, we will investigate the single-neuron dynamics, neuronal population coding properties, and their relations to neuromodulation during spatial memory consolidation. Our long-term goal is to shed insight into neuronal mechanisms of episodic memory impairment, a hallmark of early-onset Alzheimer’s Disease, and test new strategies to alleviate impaired episodic memory formation. Keywords: episodic memory formation, memory consolidation, the hippocampus, neuromodulation
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