Neuroimmunology, Endocrine and Autonomic Regulation
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Prof. Dr. Ulrike Ehlert
Topic: Endocrine and Autonomic Regulation, Neuroimmunology Website: http://www.psychologie.uzh.ch/fachrichtungen/klipsypt_en.html
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Prof. Dr. Melanie Greter Research Focus: The mononuclear phagocyte system (MPS) is defined as a group of myeloid cells comprised of monocytes, macrophages and dendritic cells. The different members of the MPS display substantial heterogeneity in terms of ontogeny, turnover and functional properties during homeostasis and inflammation. Our goal is to identify key molecules necessary for the development and function of the MPS. We will focus on microglia, a specialized brain-resident macrophage population. We aim to discover new lineage guiding transcription factors involved in microglia regulation. In addition, we will generate new mouse strains in order to specifically target microglia in vivo and to genetically manipulate CNS-invading monocytes during neuroinflammation. Keywords: Microglia, macrophages, cytokines, development, neuroinflammation Topic: Neuroimmunology Publications: pubmedWebsite: http://www.immunology.uzh.ch
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Prof. Dr. Wolfgang Langhans
Topic: Endocrine and Autonomic Regulation Website: http://www.fpb.ethz.ch/index_EN
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Prof. Dr. med. Andreas Lutterotti Research Focus: The main goal of the experimental therapies unit is to approach unmet medical needs in MS with new therapeutic strategies and to assess their safety and efficacy in early phase clinical trials. These experimental trials will be accompanied by mechanistic studies aiming to adress the mechanisms of action of the treatments and the pathogenesis of the disease. Our current research focuses on a novel strategy to induce antigen-specific tolerance in multiple sclerosis. Further we follow novel strategies to approach neuroinflammation and neuroprotection in MS. Keywords: multiple sclerosis, immune tolerance, antigen-specific, neuroprotection Topic: Neuroimmunology Publications: pubmed Website: http://www.multiplesclerosis.uzh.ch/coretopics/lutterotti.html
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Prof. Dr. med. Roland Martin Research Focus: The focus of our research is to understand better the disease heterogeneity of Multiple Sclersosis using imaging techniques (MRI and optical coherence tomography, OCT), biological markers and motor function. In the laboratory we examine disease mechanisms of MS with particular focus on cellular immunology and biochemistry. We strive at developing new treatments particularly in areas of unmet medical needs of MS such as neuroprotection, induction of tolerance and regenerative therapies. Keywords: Multiple sclerosis, T cell, antigen-specific tolerization, progressive multifocal leukoencephalopathy, experimental therapy Topic: Neuroimmunology Publications: pubmed Websites: http://www.neurologie.usz.ch/forschung/ http://www.multiplesclerosis.uzh.ch/index.html
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Prof. Dr. Francesca Peri Research Focus: Most aspects of brain development, function and, repair are not mediated by neurons alone but emerge from their interactions with other cell types. Of particular interest are microglia, the brain resident macrophages that can shape neuronal connectivity by removing dying neurons and synapses. By taking an in vivo approach that combines quantitative live imaging and cutting-edge perturbations in zebrafish, we study how microglia engulf neurons at single-cell resolution. To investigate this, we have developed tools to visualize and manipulate signals that control neuronal-microglia interactions and custom-designed microscopes that allow multi-positioning in toto brain imaging at subcellular resolution. Keywords: Microglia, neuronal cell death, development, cell biology, neuroinflammation Topic: Neuroimmunology, Endocrine and Autonomic Regulation |
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Dr. sc. nat. ETH Tobias Suter Publications: pubmed Website: http://www.dmmd.uzh.ch |
