Biomedical Technology and Imaging
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PD Dr. med. Dr. med. dent. Dominik Ettlin Center of Dental Medicine, University of Zurich Research Focus: Our clinical focus is the biopsychosocial evaluation and management of patients suffering from athrogenic, myogenic and neurogenic trigeminal pain disorders. The interdisciplinary team includes dentists, physicians, psychologists and neuroscientists. We aim at better understanding peripheral and central pathomechanisms underlying these disorders, utilizing primarily functional magnetic resonance imaging and spectroscopy (fMRI and fMRS). We developed several MR-compatible setups for reliable stimulation of extra and intraoral structures. We are also interested in behavioral aspects of pain. By collecting multicenter clinical data, we analyze potential pain etiologies and modifying factors. Keywords: trigeminal sensory system, nociception, (orofacial) pain, brainstem and cortical pain fMRI, fMRS, questionnaires, clinical pain trials Topics: Sensory Systems, Neural Basis of Behavior, Disorders of the Nervous Systems, Biomedical Technology and Imaging, cognitive neuroscience Publication: PubMed Website: http://www.zzm.uzh.ch/en/research/staff/ettlin-dominik.htm
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Dr. Tommaso Fedele, Junior Group Leader Dept. of Neurosurgery, University Hospital Zurich Research Focus: High frequency oscillations (HFO, f > 80 Hz) in intracranial EEG have been shown as a promising biomarker of of the epileptogenic zone. We standardize the detection of clinically relevant HFO in pre-operative and intra-operative invasive EEG to improve surgery outcome. We aim to extend HFO detection to non-invasive scalp EEG, using a low-noise custom-made EEG device. We also investigate epilepsy dynamics and cognitive processing at multiple spatial scales recording EEG and single unit activity in the mesial temporal lobe. Keywords: neurophysiology; epilepsy; high frequency oscillations; single unit activity Topic: Biomedical Technology and Imaging Publications: https://scholar.google.ch/citations?user=F9xZ2tEAAAAJ&hl=en |
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Prof. Dr. Roger Gassert Research Focus: We apply robotics, wearable sensor technology and non-invasive neuroimaging to the exploration, assessment and restoration of sensorimotor function, with the goal of promoting recovery following neurological injury and developing assistive technologies for the compensation of remaining deficits. Keywords: physical human-machine interaction, rehabilitation robotics, haptics, assistive technology, neural control of movement, neuroimaging, neurofeedback Topics: Sensory Systems, Motor Systems, Disorders of the Nervous System, Biomedical Technology and Imaging Publications: scholar.google.ch Website: http://www.relab.ethz.ch
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Prof. Dr. med. Alexander Huber Research Focus: In our laboratory for biomechanics of hearing we develop a comprehensive understanding and a detailed theoretical model of the physiological and pathological processes of the peripheral auditory system (from the pinna to the auditory nerve). The objectives are 1) Experimental studies of physiological and pathological processes of hearing, 2) The development of a detailed mathematical model of hearing, and 3) The optimization and development of hearing aids and hearing prostheses in collaboration with the industry. We are an interdisciplinary research team of graduates from different specialties, with competence in investigation techniques of acoustics, vibro-mechanics, fluid dynamics, electrophysiology and behavioral audiometry by taking into account the latest measurement technology. Keywords: Hearing, Biomechanics, Implants Topics: Sensory Systems, Biomedical Technology and Imaging |
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PD Dr. Dr. med. András Jakab, Junior Group Leader Keywords: magnetic resonance imaging, brain development, fetal development, image processing Topics: Disorders of the Nervous System, Biomedical Technology and Imaging Publications: https://scholar.google.ch/citations?hl=de&user=R5SzARcAAAAJ&view_op=list_works&sortby=pubdate |
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Dr. Jan Klohs Research Focus: Our research aims at developing novel non-invasive imaging techniques for the characterization of preclinical models of brain diseases. A major scientific focus is to elucidate the role of vascular dysfunction, an aberrant coagulation, inflammatory and neurodegenerative processes on brain function in cerebral ischemia and Alzheimer`s disease. To this end, we employ imaging techniques like near-infrared fluorescence imaging and magnetic resonance imaging as well as develop novel molecular imaging probes to generate a variety of target-specific, potentially translatable read-outs. For validation of the imaging marker relevant experimental and genetic mouse models of human disease, pharmacology, biochemical and immunohistochemical techniques will be employed. Since the investigated processes are generic the generated imaging marker might be applicable to a number of brain diseases. Keywords: Near-infrared fluorescence imaging, magnetic resonance imaging, preclinical models of brain diseases Topic: Biomedical Technology and Imaging Publications: pubmed
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Prof. Dr med. Spyros Kollias Research Focus: i) High-resolution structural imaging of neural tissue in vivo: a) imaging CNS myeloarchitecture with clinically relevant applications, using DTI, b) application of advanced techniques (MRS, DTI, Perfusion MRI), for increasing the specificity of MR technology ii) Multimodal imaging and connectivity mapping of degenerative CNS disease: a) functional organization of the motor and visual systems and their post-lesional reorganization, b) developing imaging and metabolic biomarkers in dementias, b) neuroimaging of migraine, c) functional analysis of brain plasticity and functional recovery of function in paraplegia, d) multimodal imaging in schizophrenia. iii) Advanced imaging of the spinal cord: including high-resolution structural MRI, MRS, and DTI with applications in oncological, traumatic and neurodegenerative pathologies. Keywords: Neuroimaging, MRI, functional brain mapping, MR Spectroscopy, Brain connectivity, multimodal imaging. Topics: Biomedical Technology and Imaging, Cognitive Neuroscience, Disorders of the Nervous System Publications: pubmed
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Prof. Dr. Vartan Kurtcuoglu Research Focus: My group’s goal is to address clinical needs through the convergence of engineering, biological and medical research. Within the neuroscience field, we focus on transport processes in the fluid spaces of the brain, namely in the cerebrospinal, interstitial and perivascular fluids. By combining computational techniques with experimental methods, we aim to understand the dynamics of cerebral fluid motion, the driving forces behind these and how they, along with the associated transport processes of metabolites and other substances, are involved in the pathogenesis of CNS disorders Keywords: volume transmission, fluid dynamics, hydrocephalus, astrocyte network, mechanosensing Topic: Computation and Modeling, Biomedical Technology and Imaging, Disorders of the Nervous System Publications: http://interfacegroup.ch/publications/journal-articles/ Website: http://interfacegroup.ch
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Dr. Ruiqing Ni, Junior Group Leader Research Focus: My research goal is to understand the mechanisms underlying Alzheimer’s disease, with a focus on detecting aberrant brain network activity, Aβ, tau and neurodegeneration by using multiscale high-resolution neuroimaging techniques (MRI, Optoacoustic tomography, PET). |
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Prof. Dr. Klaas Prüssmann
Topic: Biomedical Technology and Imaging Website: http://www.biomed.ee.ethz.ch/people/mri
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Prof. Dr. Ing. Robert Riener Research Focus: Robert Riener and the members of his Sensory-Motor Systems (SMS) Lab investigate the sensory-motor actions in and interactions between humans and machines. The research focuses on the study of human sensory-motor control, the design of novel mechatronic machines, and the investigation and optimisation of human-machine interaction. Riener’s Lab has developed famous rehabilitation robots (such as the ARMin) and virtual reality technologies applied to the area of neurorehabilitation. Main application areas are the fields of neuro-rehabilitation and sports. R. Riener is also the initiator and organiser of the Cybathlon 2016 in Kloten, Zurich. Keywords: Neurorehabilitation, rehabilitaiton robotics, motor learning, control of motion, biomechatronics
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Prof. Dr. Markus Rudin
Topic: Biomedical Technology and Imaging Website: http://www.biomed.ee.ethz.ch/people/rudinma
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Dr. Aiman Saab, Junior Group Leader Research Focus: Myelinating oligodendrocytes and astrocytes are suggested to play an important role in maintaining neuronal functions and long-term integrity. In white matter tracts, axons are almost completely ensheathed by myelin and the axonal compartment may receive metabolic support from surrounding glial cells. Our research focuses on understanding the molecular mechanisms governing neuron-glial interactions and metabolic cooperation. How do myelinating oligodendrocytes and astrocytes sense neuronal activity and how are these signals translated into maintaining neuronal functions in the young and aging brain? Could perturbations in glial metabolic support to axons impact the etiology and pathogenesis of age-related neuropsychiatric and degenerative diseases? To address these questions we combine molecular genetics, electrophysiology, in vivo and ex vivo two-photon imaging, histology, electron microscopy and behavioural studies in various transgenic and knockout mouse models to investigate cellular mechanisms regulating intercellular communication, brain energy homeostasis and cellular integrity. |
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Prof. Johannes Sarnthein Research Focus: Establish neurophysiological biomarkers to improve the outcome of neurosurgical interventions. We correlate intraoperative measurements with postoperative outcome to optimize the neurophysiological guidance of the surgeon. We analyze data obtained during surgery to investigate the physiological mechanisms involved. For example, high-frequency oscillations (HFO) are a promising new marker for epileptogenic brain tissue in intracranial recordings in epilepsy patients, both before and after resection of the epileptogenic zone. Keywords: intraoperative neuromonitoring; patient registry; tumor; epilepsy Topic: Biomedical Technology and Imaging Publications: pubmed scholar.google Website: http://www.ini.uzh.ch/~johannes/ |
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