Neuroimmunology, Endocrine and Autonomic Regulation

Ulrike Ehlert


Prof. Dr. Ulrike Ehlert
Department of Psychology, University of Zurich


Topic: Neuroimmunology, Endocrine and Autonomic Regulation



Melanie Greter


Prof. Dr. Melanie Greter
Experimental Immunology, University of Zurich

Research Focus: The mononuclear phagocyte system (MPS) is defined as a group of myeloid cells comprised of monocytes, macrophages and dendritic cells. The different members of the MPS display substantial heterogeneity in terms of ontogeny, turnover and functional properties during homeostasis and inflammation. Our goal is to identify key molecules necessary for the development and function of the MPS. We will focus on microglia, a specialized brain-resident macrophage population. We aim to discover new lineage guiding transcription factors involved in microglia regulation. In addition, we will generate new mouse strains in order to specifically target microglia in vivo and to genetically manipulate CNS-invading monocytes during neuroinflammation.

Keywords: Microglia, macrophages, cytokines, development, neuroinflammation

Topic: Neuroimmunology

Publications: PubMed



Roland Martin


Prof. Dr. med. Roland Martin
Dept of Neuroimmunology and MS Research (nims), Neurology Clinic, University Hospital Zurich

Research Focus: The focus of our research is to understand better the disease heterogeneity of Multiple Sclersosis using imaging techniques (MRI and optical coherence tomography, OCT), biological markers and motor function. In the laboratory we examine disease mechanisms of MS with particular focus on cellular immunology and biochemistry. We strive at developing new treatments particularly in areas of unmet medical needs of MS such as neuroprotection, induction of tolerance and regenerative therapies.

Keywords:  Multiple sclerosis, T cell, antigen-specific tolerization, progressive multifocal leukoencephalopathy, experimental therapy

Topic: Neuroimmunology

Publications: PubMed



Peri Francesca


Prof. Dr. Francesca Peri
Institute for Molecular Life Sciences, University of Zurich

Research Focus: Most aspects of brain development, function and, repair are not mediated by neurons alone but emerge from their interactions with other cell types. Of particular interest are microglia, the brain resident macrophages that can shape neuronal connectivity by removing dying neurons and synapses. By taking an in vivo approach that combines quantitative live imaging and cutting-edge perturbations in zebrafish, we study how microglia engulf neurons at single-cell resolution. To investigate this, we have developed tools to visualize and manipulate signals that control neuronal-microglia interactions and custom-designed microscopes that allow multi-positioning in toto brain imaging at subcellular resolution.

Keywords: Microglia, neuronal cell death, development, cell biology, neuroinflammation

Topic: Neuroimmunology, Endocrine and Autonomic Regulation

Weiss Tobias


Dr. med. Dr. sc. nat. Tobias Weiss
Department of Neurology, University Hospital and University of Zurich

Research Focus: Malignant brain tumors are devastating diseases with a poor prognosis and an urgent need for better therapies. We are developing novel therapeutic approaches against primary brain tumors and brain metastasis, with a focus on novel cancer immunotherapies. For this, we use state-of-the-art disease models including cell lines, orthotopic fully immunocompetent mouse models and patient samples. In collaboration with groups at the University of Zurich and ETH Zurich, we apply cutting-edge methods in genomics, proteomics and imaging to gain a deep mechanistical understanding of these diseases. The goal of our research is the translational of novel treatment strategies to patients.

Keywords: Brain Tumors, Immunotherapy, drug-development, multi-omics

Topic: Disorders of the Nervous System, Neuroimmunology

Publications: PubMed Google Scholar